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    1. Chromosomes and Gene Expression

    CyAbrB2 is a nucleoid-associated protein in Synechocystis controlling hydrogenase expression during fermentation

    Ryo Kariyazono, Takashi Osanai
    cyAbrB2, the global transcriptional factor conserved in cyanobacteria, is the nucleoid-associated protein, which is the first report in cyanobacteria.
    1. Structural Biology and Molecular Biophysics

    Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

    Po-Lin Chiu, Juan D Orjuela ... Thomas Walz
    Electron crystallography and molecular dynamics simulations show that a cholesterol sandwiched in between two neighboring aquaporin-0 tetramers stabilizes the association between the tetramers and thus promotes array formation.
    1. Neuroscience

    Future movement plans interact in sequential arm movements

    Mehrdad Kashefi, Sasha Reschechtko ... J Andrew Pruszynski
    To ensure smooth sequential actions, reaches to at least two future targets are planned during the execution of the current reach and the planning processes of the future reaches interact.
    1. Structural Biology and Molecular Biophysics

    Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

    Dipti Ranjan Lenka, Shakti Virendra Dahe ... Atul Kumar
    The new insights into the activation mechanism of Parkin E3 ligase could be useful for designing small-molecule activators against Parkinson’s disease.
    1. Plant Biology

    Unraveling the role of urea hydrolysis in salt stress response during seed germination and seedling growth in Arabidopsis thaliana

    Yuanyuan Bu, Xingye Dong ... Shenkui Liu
    Salt stress triggers excessive hydrolysis of arginine-derived urea in Arabidopsis thaliana, raising cytoplasmic pH and inhibiting seed germination and seedling growth, providing new insights into the relationship between seed nitrogen mobilization and seed germination inhibition.
    1. Immunology and Inflammation

    Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics

    Youxi Liu, Meimei Yin ... Ling-juan Zhang
    Dermal preadipocytes produce T cell chemokines in response to IFNγ, driving the recruitment and activation of type 1 effector T cells in allergic contact dermatitis.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    MDverse, shedding light on the dark matter of molecular dynamics simulations

    Johanna KS Tiemann, Magdalena Szczuka ... Pierre Poulain
    Identifying, indexing, and annotating molecular dynamics simulations open data is essential to ensure their proper reuse.
    1. Neuroscience

    Quantitative modeling of the emergence of macroscopic grid-like representations

    Ikhwan Bin Khalid, Eric T Reifenstein ... Richard Kempter
    A computational study quantifies how macroscopic grid-like representations may emerge in the human brain using different hypotheses and navigation patterns, indicating the need to further characterize properties of grid cells.
    1. Developmental Biology
    2. Neuroscience

    Adverse impact of female reproductive signaling on age-dependent neurodegeneration after mild head trauma in Drosophila

    Changtian Ye, Ryan Ho ... James Q Zheng
    A head concussion model in fruit flies reveals that early-life exposure to mild concussions significantly increases the risk of late-life neurodegeneration, with females especially vulnerable due to reproductive factors.
    1. Cancer Biology

    Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

    Phaedra C Ghazi, Kayla T O'Toole ... Martin McMahon
    Inhibiting KRASG12C and ULK-mediated autophagy is a novel treatment strategy to control the growth of KRASG12C-driven lung cancer in preclinical models of lung cancer.