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Page 307 of 1,780
    1. Cell Biology
    2. Developmental Biology

    Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion

    Houyu Zhang, Yan Li ... Meng Xie
    A brown-to-white adipogenic transdifferentiation process in the periureter region of mouse renal adipose tissue gives rise to a population of cold-inducible adipocytes with a transcriptome distinct from subcutaneous beige adipocytes.
    1. Neuroscience

    Coordinated head direction representations in mouse anterodorsal thalamic nucleus and retrosplenial cortex

    Marie-Sophie H van der Goes, Jakob Voigts ... Mark T Harnett
    Dual site recordings of mouse anterodorsal thalamic nucleus and retrosplenial cortex reveal near 0-ms lag between the head direction representations of the two regions after cue rotations and correlated drift in darkness.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans

    Florian Bénitière, Anamaria Necsulea, Laurent Duret
    Variation in the rate of alternative splicing across animals are mainly driven by differences in the rate of splicing errors.
    1. Neuroscience

    Combinatorial expression of γ-protocadherins regulates synaptic connectivity in the mouse neocortex

    Yi-jun Zhu, Cai-yun Deng ... Hua-tai Xu
    For neurons to prevent undesirable synaptic connections in the brain, the combinatorial expression of γ-PCDH is essential.
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    1. Neuroscience

    Neural attentional filters and behavioural outcome follow independent individual trajectories over the adult lifespan

    Sarah Tune, Jonas Obleser
    Individual listening behaviour and neural filtering ability follow independent developmental trajectories in a large, N = 105, cohort of ageing individuals.
    1. Neuroscience
    2. Physics of Living Systems

    Neural criticality from effective latent variables

    Mia C Morrell, Ilya Nemenman, Audrey Sederberg
    Signatures of criticality that have been observed across diverse neural systems, such as power-law avalanche distributions and exponent relationships, can arise without fine-tuning in networks coupled to latent, dynamical variables.
    1. Neuroscience

    Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons

    Prithviraj Rajebhosale, Mala R Ananth ... David A Talmage
    Functionally refined organization of learned and innate threat encoding in the cholinergic basal forebrain.
    1. Medicine

    Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis

    Kentaro Homan, Tomohiro Onodera ... Norimasa Iwasaki
    Corefucosylation contributes to the maintenance of the articular cartilage phenotype and depletion of FUT8 inhibits recovery from cartilage damage and promotes cartilage degeneration.
    1. Immunology and Inflammation

    Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium

    Izumi Ohigashi, Andrea J White ... Yousuke Takahama
    Thymocyte-attracting CCL21-expressing embryonic mTECs carry a developmental potential to give rise to self-antigen-displaying Aire-expressing mTECs.
    1. Cell Biology

    Sorting of secretory proteins at the trans-Golgi network by human TGN46

    Pablo Lujan, Carla Garcia-Cabau ... Felix Campelo
    TGN46 is a cargo receptor, with its luminal domain being necessary and sufficient to load soluble secretory proteins into transport carriers for export out of the trans-Golgi network.