Browse the latest research

Page 365 of 1,793
    1. Neuroscience

    ACC neural ensemble dynamics are structured by strategy prevalence

    Mikhail Proskurin, Maxim Manakov, Alla Karpova
    Anterior Cingulate Cortex displays robust tracking during strategy execution of a summary statistic for that strategy in recent behavioral history, suggesting a role for this brain region in estimating which actions promote the occurrence of events in the environment.
    1. Developmental Biology

    MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters

    Filippo M. Massa, Fariba Jian-Motamedi ... Andreas Schedl
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Cell Biology

    Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB

    Ling-Yun Zhou, Chen-Xi Jin ... Hao Wu
    In hair cells, the development and maintenance of the F-actin-enriched stereocilia and cuticular plates are differentially regulated by transcription factors SRF and MRTFB, and SRF–CNN2 is required for modulating actin dynamics of the stereocilia and cuticular plate.
    1. Computational and Systems Biology

    Shared and distinct pathways and networks genetically linked to coronary artery disease between human and mouse

    Zeyneb Kurt, Jenny Cheng ... Xia Yang
    Cross-species multiomics network modeling revealed tissue-specific regulatory genes, pathways, and networks shared between mouse and human or unique to each species for atherosclerosis and coronary artery disease.
    1. Neuroscience

    Postsynaptic mitochondria are positioned to support functional diversity of dendritic spines

    Connon I Thomas, Melissa A Ryan ... Benjamin Scholl
    Correlated light and electron microscopy of cortical neurons reveals a local organization of mitochondria near dendritic spines with diverse functional properties.
    1. Genetics and Genomics
    2. Neuroscience

    Opposing chemosensory functions of closely related gustatory receptors

    Ji-Eun Ahn, Hubert Amrein
    Live imaging and taste behavior analyses show that related members of the Gr28 gene subfamily are expressed in largely non-overlapping sets of neurons and mediate opposing taste behaviors.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A timeline of bacterial and archaeal diversification in the ocean

    Carolina A Martinez-Gutierrez, Josef C Uyeda, Frank O Aylward
    Phylogenomics reveals the timeline over which marine bacteria and archaea colonized the oceans and shows the geological context of their diversification.
    1. Cell Biology

    Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress

    Samarpan Maiti, Kaushik Bhattacharya ... Didier Picard
    Human cells adapt to chronic mild stresses, such as slightly elevated temperature, by getting larger in a process that couples increased translation to increased cell size in an Hsp90-dependent manner.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

    Vanessa Dumeaux, Samira Massahi ... Michael T Hallett
    Candida albicans cells respond in two distinct ways to fluconazole exposure where cells enter the Ribo-dominant state characterized by an upregulation of ribosomal-related proteins and processes, or cells enter the Stress-dominant state characterized by the upregulation of stress responses.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence

    Zachary Baker, Molly Przeworski, Guy Sella
    Modeling the evolution of PRDM9 in light of recent results implicating the importance of PRDM9 binding symmetry suggests the advantage of new PRMD9 alleles is in limiting the number of binding sites used effectively rather than increasing net binding.