Melanopsin phototransduction targets distinct complements of transduction channels across intrinsically photosensitive retinal ganglion cell subtypes and does not require hyperpolarization-activated cyclic nucleotide-gated channels.
The hippocampus demonstrates flexible coding during memory encoding, prioritizing either distance or time information based on the specific requirements of the experiment.
A comprehensive platform is established for the evaluation of both current and future individuals afflicted with the UBA5-associated developmental and epileptic encephalopathy.
Inhibition of RyR2 hyperactivity with dantrolene not only prevents VT/VF and SCD but also heart failure by mitigating calcium dysfunction in pressure-overloaded hearts.
Mügen Terzioglu, Kristo Veeroja ... Howard T Jacobs
Based on two independent methods, mitochondria operate at temperatures up to 15°C hotter than ambient, adjusting their heat production so as to maintain temperature in face of physiological stresses.
A novel mathematical method for screening new drugs for pro-arrhythmic cardiotoxicity without using animals or costly drug-specific computer simulations is proposed.
When the acquisition of reward becomes effortful, marmosets choose to work longer, delaying their harvest, but slow their movements, reducing energy consumption.
