Browse the latest research

Page 367 of 1,792
    1. Neuroscience

    Associative memory neurons of encoding multi-modal signals are recruited by neuroligin-3-mediated new synapse formation

    Yang Xu, Tian-liang Cui ... Jin-Hui Wang
    The coactivity of cortical neurons in associative learning recruits them as associative memory cells based on their synapse interconnections by neuroligin-3-mediated synapse formation, which endorses the first order and the second order of associative memory.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Avoiding false discoveries in single-cell RNA-seq by revisiting the first Alzheimer’s disease dataset

    Alan E Murphy, Nurun Fancy, Nathan Skene
    Reanalysis reveals the impact of quality control and differential analysis methods on the discovery of disease-associated genes on the first Alzheimer's disease single-nucleus RNA-seq dataset.
    1. Neuroscience

    Zona incerta distributes a broad movement signal that modulates behavior

    Sebastian Hormigo, Ji Zhou ... Manuel Castro-Alamancos
    The zona incerta distributes a broad corollary signal of movement occurrence to its projection sites, which regulates but does not drive behavior.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Indole produced during dysbiosis mediates host–microorganism chemical communication

    Rui-Qiu Yang, Yong-Hong Chen ... Cheng-Gang Zou
    In C. elegans, neuronic TRPA-1 senses bacterial accumulation by detecting indole production to up-regulate lysozyme genes via FOXO/DAF-16 in the intestine, thereby delaying microbial dysbiosis.
    1. Cell Biology
    2. Medicine

    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

    Thao DV Le, Dianxin Liu ... Julio E Ayala
    The ability of the therapeutic glucagon-like peptide-1 receptor agonist liraglutide to promote weight loss is partly dependent on signaling via PKA-dependent phosphorylation of the mTORC1 regulator protein Raptor.
    1. Epidemiology and Global Health
    2. Medicine

    Association between bisphosphonate use and COVID-19 related outcomes

    Jeffrey Thompson, Yidi Wang ... Ulrich H von Andrian
    A claims-based retrospective cohort study shows that patients who used bisphosphonates between 01/01/2019 and 02/29/2020 had dramatically reduced odds of SARS-CoV-2 testing, COVID-19 diagnosis, and COVID-19-related hospitalizations during the initial surge of the COVID-19 pandemic in the US.
    1. Neuroscience

    Event-related modulation of alpha rhythm explains the auditory P300-evoked response in EEG

    Alina Studenova, Carina Forster ... Vadim Nikulin
    The decrease in alpha rhythm amplitude in the parietal regions after the presentation of a deviant auditory stimulus gives rise to a part of the P300-evoked response.
    1. Neuroscience

    Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-making

    Stijn A Nuiten, Jan Willem de Gee ... Simon van Gaal
    Pharmacologically elevated catecholamine levels and spatial attention jointly shape perceptual decision-making, revealed by unique, similar, and interactive effects on behavior, drift diffusion modeling parameters, and electrophysiology.
    1. Developmental Biology

    Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for Groucho in regulating a proliferative-invasive cellular switch in C. elegans

    Taylor N Medwig-Kinney, Brian A Kinney ... David Q Matus
    Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for members of the Groucho/TCF repressive complex in maintaining non-invasive cell fate in C. elegans.
    1. Medicine

    A single-cell atlas depicting the cellular and molecular features in human anterior cruciate ligamental degeneration: A single cell combined spatial transcriptomics study

    Runze Yang, Tianhao Xu ... Weili Fu
    Single-cell combined spatial transcriptomics provides the molecular foundation for investigating how ligamental cell identities, biochemical functions, and interactions contributed to the ligamental degeneration process.