A rare human mitofusin (MFN) 2 mutation that uniquely impaired Parkin-mediated mitophagy evoked developmental heart disease and increased myocardial sensitivity to doxorubicin in mice, differentiating it from mitophagy-competent MFN2 mutations that cause neuropathy and implicating mitophagy in clinical cardiomyopathy.
Neurons in the mouse hippocampus, known as place cells, surprisingly show movie-fields, where they reliably encode distinct segments of a black-and-white, silent movie, even without any task demand or rewards.
A structural and biochemical study reveals the molecular mechanism of the predator–prey associations of Aplysia kurodai and brown algae (akuBGL–phlorotannin/laminarin–EHEP system), which has high-potential applications in the biotechnology industry.
Experimental manipulations and a mechanical model of the fiber reveal that the Reissner fiber is under heterogenous tension in vivo, and interacts with the motile cilia of diverse cells contacting the cerebrospinal fluid.
Dysmyelination of GABAergic hippocampal interneurons causes mislocalization of axonal ionic channels and disturbs their intrinsic physiological properties, suggesting that it may contribute to cognitive deficits observed in multiple sclerosis patients.
A computational neuroanatomy analysis of cerebellar and cerebral folding in 56 mammalian species reveals groups of highly variable 'diverse' phenotypes, and strongly conserved 'stable' phenotypes, providing new insights into the diversity, evolution, and influence of cortical folding on brain organisation.
Maruthi Kumar Pabba, Christian Ritter ... M Cristina Cardoso
Live cell tracking of labeled DNA reveals that replisome loading rather than DNA synthesis decreases the chromatin motion during S-phase in human cells.
