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Live human pancreatic α-cells can be purified effectively using zinc-based reaction probe diacetylated Zinpyr1 and cultured as pseudoislets without losing their viability and function.

The C. elegans canonical DBL1/TGFβ signaling pathway is not only regulated in response to bacterial challenges, but also appropriately tailors behaviors and molecular immune responses to bacterial challenges, and animals lacking DBL1 respond to specific bacteria as more harmful.

SPOT-MAS (screening for the presence of tumor by methylation and size) is an affordable and effective multi-cancer early detection test analyzing multiple features of circulating tumor DNA.

Improvement in levels of anxious-depression corresponds with increased confidence in performance among individuals receiving mental health treatment within a large longitudinal dataset.

Deletion of optic atrophy 1 in brown adipose tissue induces secretion of growth differentiation factor 15 as a batokine to attenuate diet-induced obesity and improve glucose clearance, hepatic steatosis, and thermoregulation in mice by increasing energy expenditure.

Impairing TDP-43 RNA-binding capacity through a single acetylation-mimic mutation alters TDP-43 function and recapitulates biochemical, molecular, and behavioral features of sporadic TDP-43 proteinopathies, thus providing opportunities for new research into pathogenic mechanisms and therapeutic interventions.

A new mass spectrometry-based method to identify and quantify changes in a subcellular local protein environment shows the impact of deletion of a kinase the human malaria parasites export into the host cell.

Circulating high-molecular-weight (cHMW) adiponectin levels increased with age until centenarians, and the contribution of known major factors associated with cHMW adiponectin levels including BMI varied with age, suggesting that its physiological significance also varies with age in the oldest old.

Predicting multivariate phenotypic evolution.