Directly manipulating cellular energy levels suppresses catabolic pathways and enhances mitochondrial maintenance, establishing bioenergetic homeostasis as a fundamental driver of cellular longevity.
Olivia G Waltner, April A Apfelbaum ... Scott N Furlan
In Ewing sarcoma, a mesenchymal gene program normally repressed by the oncogenic fusion is reactivated by TGF-β signaling, and is associated with more aggressive disease.
Tamara Gedankien, Jennifer Kriegel ... Joshua Jacobs
Cholinergic blockade via scopolamine reveals that hippocampal theta oscillations are essential for encoding rather than retrieval, suggesting these rhythms represent a dedicated neural state for memory formation.
