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Page 4 of 1,887
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Selective suppression and biasing of chemokine receptors CCR9 and ACKR4 through targeting CCL25 with de novo miniproteins

    Bas de Boer, Thomas D Lamme ... Christopher T Schafer
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Use-dependent regulation of the axonal action potential in parvalbumin-expressing interneurons

    Sophie R Liebergall, Ethan M Goldberg
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Genetics and Genomics
    2. Cancer Biology

    Functional characterization of a multi-cancer risk locus on chromosome band 2q33.1 near CASP8

    Hyunkyung Kong, Jiyeon Choi ... Kevin M Brown
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling

    Nevin K Zacharia, Stefanie Kuhns ... Esben Lorentzen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Developmental Biology

    Junctional and Actomyosin Dynamics Drive Endothelial Cell Rearrangements during Vascular Tube Formation

    Ludovico Maggi, Jianmin Yin ... Heinz-Georg Belting
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Continuous flash suppression of neural responses and population orientation coding in macaque V1

    Cai-Xia Chen, Xin Wang ... Cong Yu
    Continuous flash suppression reduces V1 orientation responses in an ocular-dominance-dependent manner, which may still allow low-level coarse orientation discrimination but provide insufficient information for higher-level visual and cognitive tasks.
    1. Cancer Biology
    2. Cell Biology

    HER2-driven mammary tumorigenesis enhances bioenergetics despite reductions in mitochondrial content

    Sara M Frangos, Henver S Brunetta ... Graham P Holloway
    Multi-omic and bioenergetic profiling in a HER2-driven mouse model of mammary cancer reveals that reduced mitochondrial content does not limit tumor respiratory capacity, which is instead dramatically elevated compared to benign mammary tissue.
    1. Computational and Systems Biology

    Dynamic architecture of mycobacterial outer membranes revealed by all-atom simulations

    Turner P Brown, Matthieu Chavent, Wonpil Im
    The first all-atom models of the mycobacterial outer membrane reveal how lipid organization and asymmetry generate a structurally heterogeneous barrier that underlies its unique permeability properties.
    1. Computational and Systems Biology

    Fully computational design of PAM-relaxed Staphylococcus aureus Cas9 with expanded targeting capability using UniDesign

    Youcai Xiong, Li-Kuang Tsai ... Xiaoqiang Huang
    A fully computationally designed SaCas9 variant expands PAM recognition to NNNRRT, achieving up to 116-fold higher editing at noncanonical sites while matching the performance of experimentally evolved variants.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Natural xanthones as α-Mangostin induce vasorelaxation involving key gating residues in the S6 domain of BK channels

    Soenke Cordeiro, Robert Patejdl ... Marianne A Musinszki
    Identification of mangostins as potent BK channel activators links natural xanthones to vascular smooth muscle relaxation, providing a mechanistic basis for their reported antihypertensive effects.
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