Browse the latest research

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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Timely vaccine strain selection and genomic surveillance improve evolutionary forecast accuracy of seasonal influenza A/H3N2

    John Huddleston, Trevor Bedford
    Reducing vaccine development time from 12 months to 6 reduces forecasting error by 25%, while reducing lags in genome sequence submission reduces uncertainty of current clade frequencies by 50%.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

    Samantha J Cassell, Weiyan Li ... Jonathan R Whicher
    Cryo-EM and electrophysiology reveal the mechanism of SK2 channel modulation by the bee toxin apamin and small molecules, providing insights that enable the rational design of targeted SK2 channel therapeutics.
    1. Developmental Biology
    2. Neuroscience

    Ptbp1 is not required for retinal neurogenesis and cell fate specification

    Haley Appel, Rogger P Carmen-Orozco ... Seth Blackshaw
    Loss of function of Ptbp1 in retinal progenitors leads to changes in RNA splicing but does not affect neurogenesis and cell fate specification.
    1. Neuroscience

    Fear conditioning biases olfactory sensory neuron expression across generations

    Clara W Liff, Yasmine R Ayman ... Bianca J Marlin
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Modality-Agnostic Decoding of Vision and Language from fMRI

    Mitja Nikolaus, Milad Mozafari ... Rufin VanRullen
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Evolutionary remodeling of non-canonical ORF translation in mammals

    Yue Chang, Tianyu Lei ... Hong Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Neuroscience

    The electrogenicity of the Na+/K+-ATPase poses challenges for computation in highly active spiking cells

    Liz Weerdmeester, Jan-Hendrik Schleimer, Susanne Schreiber
    The electrogenic Na+/K+-ATPase generates a slow activity-dependent feedback signal that influences the computation of excitable cells and requires additional compensatory mechanisms during periods of high sustained activity.
    1. Cell Biology

    Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

    Hannah Neiswender, Jessica E Pride ... Graydon B Gonsalvez
    Disease-associated mutations in BICD2 result in loss- and gain-of-function interactions and dynein hyperactivity.
    1. Neuroscience

    Dorsal hippocampus mediates light–tone associations in male mice

    Julia S Pinho, Carla Ramon-Duaso ... Arnau Busquets-Garcia
    A light–tone sensory preconditioning task in male mice is developed revealing sex differences and demonstrating that dorsal, but not ventral, hippocampal CaMKII-positive neurons encode innocuous stimulus associations.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The primate Major Histocompatibility Complex as a case study of gene family evolution

    Alyssa Lyn Fortier, Jonathan K Pritchard
    The Major Histocompatibility Complex region evolves via gene birth-and-death, resulting in short-lived genes, rapidly expanding gene subfamilies, and many gene fragments.