Browse the latest research

Page 5 of 1,887
    1. Computational and Systems Biology

    Fully computational design of PAM-relaxed Staphylococcus aureus Cas9 with expanded targeting capability using UniDesign

    Youcai Xiong, Li-Kuang Tsai ... Xiaoqiang Huang
    A fully computationally designed SaCas9 variant expands PAM recognition to NNNRRT, achieving up to 116-fold higher editing at noncanonical sites while matching the performance of experimentally evolved variants.
    1. Developmental Biology

    HSD17B7 is required for the function of sensory hair cells by regulating cholesterol synthesis

    Yuqian Shen, Ziyang Wang ... Dong Liu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Developmental Biology

    A stress-responsive morphogenetic program of the uterine epithelium safeguards the establishment of early pregnancy

    Chihiro Ishizawa, Shizu Aikawa ... Yasushi Hirota
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions

    Richa Sirmaur, Rishikesh Narayanan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Defining the Antigenic Topology and Prospective Binding Breadth of Vaccination-induced SARS-CoV-2 Neutralizing Antibodies

    Deepika Jaiswal, Clara G Altomare ... Goran Bajic
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Programmed Delayed Splicing: A Mechanism for Timed Inflammatory Gene Expression

    Jacob S Dearborn, Luke Frankiw ... Devdoot Majumdar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Purified Zymogens Reveal Mechanisms of Snake Venom Metalloproteinase Auto-Activation

    Sophie Hall, Iara Aimê Cardoso ... Christiane Schaffitzel
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Cell Biology

    An ancient transcription factor functions as the master regulator of primary cilia formation

    Weihua Wang, Xiqi Zhang ... Zhangfeng Hu
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency

    Eliezer Heller, Lucas dos Santos Dias, Michail S Lionakis
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology
    2. Computational and Systems Biology

    Geometry shapes cytoplasmic Cdk1 waves that drive cortical dynamics

    Daniel Cebrián-Lacasa, Marcin Leda ... Lendert Gelens
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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