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    1. Neuroscience

    Individuality across environmental context in Drosophila melanogaster

    Thomas F Mathejczyk, Cara Knief ... Gerit A Linneweber
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

    Luke J Dillard, Gina M Calabrese ... Charles R Farber
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Compelling
    • Solid
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Importance of higher-order epistasis in protein sequence-function relationships

    Palash Sethi, Juannan Zhou
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology

    Aging-associated Increase of GATA4 levels in Articular Cartilage is Linked to Impaired Regenerative Capacity of Chondrocytes and Osteoarthritis

    Meagan J Makarczyk, Yiqian Zhang ... Hang Lin
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Compelling
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Adrenomedullin restores the human cortical interneurons migration defects induced by hypoxia

    Alyssa Puno, Wojciech P Michno ... Anca M Pasca
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    Treacle and MDC1 coordinate rDNA break repair by homologous recombination

    Andrea Haenel, Johannes Leyrer, Manuel Stucki
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Crossover in Aromatic Amino Acid Interaction Strength: Tyrosine vs. Phenylalanine in Biomolecular Condensates

    David De Sancho, Xabier López
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Online reinforcement learning of state representation in recurrent network supported by the power of random feedback and biological constraints

    Takayuki Tsurumi, Ayaka Kato ... Kenji Morita
    Recurrent neural network and its readout (cortex–striatum) can learn state representation and value using online random-weight feedback of temporal-difference reward-prediction-error (dopamine) through feedback alignment or biological non-negative-weight constraint-induced loose alignment.
    1. Cell Biology

    Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

    Akinori Endo, Chikage Takahashi ... Yukiko Yoshida
    Ubiquitin accumulated on damaged lysosomes activates TAB–TAK1–IKK–NF-κB axis and remodels proteome through gene expression for cell survival and cell-cell communication.
    1. Evolutionary Biology

    Forecasting protein evolution by integrating birth-death population models with structurally constrained substitution models

    David Ferreiro, Luis Daniel González-Vázquez ... Miguel Arenas
    Forecasting protein evolution in terms of folding stability using state-of-the-art population genetics and substitution models is feasible in rugged fitness landscapes, whereas forecasting exact amino acid sequences remains more challenging.
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