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    1. Cell Biology

    Defective neuronal differentiation in Lowe syndrome is associated with mitochondrial dysfunction and impaired cilia-related Sonic Hedgehog signaling

    Grzegorz Walkiewicz, Siyu Chen ... Yang Sun
    OCRL deficiency is associated with mitochondrial dysfunction, altered ciliary signaling, and disrupted neural cell-state regulation across multiple experimental models of Lowe syndrome.
    1. Physics of Living Systems

    Intracellular mechanical fingerprint reveals cell type-specific mechanical differences

    Till M Muenker, Kerstin von Roden ... Timo Betz
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Plant Biology

    Improving rice drought tolerance through host-mediated microbiome selection

    Alex Styer, Dean Pettinga ... Devin Coleman-Derr
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    VDAC2 stabilizes a membrane-inserted, primed intermediate of BAX activation

    Varun Ravishankar, Laidy M Alvero-González ... Lucie Bergdoll
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology

    Loss of canonical sex steroid signaling correlates with prostate cancer progression and induces tumor escape in Drosophila

    Marine Vialat, Elissa Baabdaty ... Cyrille de Joussineau
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Probing the role of sequential sampling and integration in decisions about protracted, noiseless stimuli

    Hadiseh Hajimohammadi, Kieran S Mohr ... Simon P Kelly
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Blood-derived dietary protein promotes sleep in the mosquito Aedes aegypti

    Jiwei Zhang, Hitoshi Tsujimoto ... Alex C Keene
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    The C. elegans gustatory receptor homolog LITE-1 is a chemoreceptor required for diacetyl avoidance

    Alan Koh, Eduard Bokman ... André EX Brown
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Stem Cells and Regenerative Medicine

    Synergistic inhibition of Notch signaling and forced cell cycle re-entry drive Müller glia reprogramming in uninjured mouse retina

    Baoshan Liao, Chengshang Lyu ... Wenjun Xiong
    Stimulating cell cycle entry and suppressing Notch signaling drive mammalian Müller glia to proliferate and generate diverse, long-surviving neuron-like cells, offering insights into overcoming retinal regeneration barriers.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites

    Deborah Maus, Elyzana Putrianti ... Martin Blume
    Inhibiting the mitochondrial bc1-complex disrupts energy production in mature Toxoplasma gondii bradyzoites, suggesting a metabolic vulnerability in the parasite's chronic, drug-resistant stage.
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