A novel mathematical method for screening new drugs for pro-arrhythmic cardiotoxicity without using animals or costly drug-specific computer simulations is proposed.
Hirofumi Noguchi, Jessica Chelsea Arela ... Samuel Pleasure
Hilar mossy cells control seizure-dependent dentate neurogenesis and stem cell quiescence by activity-dependent control of Sonic hedgehog production and signaling.
When the acquisition of reward becomes effortful, marmosets choose to work longer, delaying their harvest, but slow their movements, reducing energy consumption.
The ZEB2/ACSL4 axis acts as a novel metastatic metabolic pathway that stimulates both lipogenesis and fatty acid oxidation, resulting in enhanced breast cancer invasion and metastasis.
Inhibition of RyR2 hyperactivity with dantrolene not only prevents VT/VF and SCD but also heart failure by mitigating calcium dysfunction in pressure-overloaded hearts.
Mügen Terzioglu, Kristo Veeroja ... Howard T Jacobs
Based on two independent methods, mitochondria operate at temperatures up to 15°C hotter than ambient, adjusting their heat production so as to maintain temperature in face of physiological stresses.
A comprehensive platform is established for the evaluation of both current and future individuals afflicted with the UBA5-associated developmental and epileptic encephalopathy.
Xiang Wang, Vitaliy V Bondar ... Anastasia G Henry
Rab12 was identified as a key modulator of LRRK2-dependent Rab phosphorylation that mediates the recruitment of LRRK2 to lysosomes in response to damage.
