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Page 483 of 1,892
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Sexual dimorphic regulation of recombination by the synaptonemal complex in C. elegans

    Cori K Cahoon, Colette M Richter ... Diana E Libuda
    Developing eggs and sperm differentially regulate specific steps of meiotic DNA repair by altering the composition and dynamics of proteins within synaptonemal complex.
    1. Genetics and Genomics
    2. Neuroscience

    Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

    Muniesh Muthaiyan Shanmugam, Jyotiska Chaudhuri ... Pankaj Kapahi
    Advanced glycation end-products (compounds which make the food appetizing and aromatic) intricately modulate organism’s homeostatic and hedonistic signaling pathways thereby inducing preferential consumption of excess nutrients offering preliminary insights into overconsumption of modern-day processed food.
    1. Ecology

    Meta-analysis reveals glucocorticoid levels reflect variation in metabolic rate, not ‘stress’

    Blanca Jimeno, Simon Verhulst
    Glucocorticoids are assumed to reflect 'stress,' but they increase proportionally to the increase in metabolic rate induced by stressors, leading us to propose that glucocorticoids reflect metabolic rate, not stress.
    1. Evolutionary Biology

    Evolutionary consequences of nascent multicellular life cycles

    Jennifer T Pentz, Kathryn MacGillivray ... William C Ratcliff
    Clonal development, but not aggregation, promotes the transition of Darwinian individuality from cells to groups, emphasizing the fundamental role of initial multicellular life cycles in the evolution of multicellularity.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Within-host diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks

    Arturo Torres Ortiz, Michelle Kendall ... Louis Grandjean
    The use of within-host pathogen genomic sequence data can be used to improve phylogenetic and transmission estimates.
    1. Neuroscience

    Quantifying decision-making in dynamic, continuously evolving environments

    Maria Ruesseler, Lilian Aline Weber ... Laurence Tudor Hunt
    Human behaviour in a continuous decision making task adapts to the overall statistics of the sensory environment, and these adaptations are also reflected in changes in neural responses to incoming sensory evidence.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases

    Aarya Venkat, Grace Watterson ... Natarajan Kannan
    Isoform-specific variations in doublecortin-like kinases offer a new framework for understanding kinome-wide modulation of protein stability and catalytic activity.
    1. Genetics and Genomics
    2. Medicine

    Association between APOL1 risk variants and the occurrence of sepsis in Black patients hospitalized with infections: a retrospective cohort study

    Lan Jiang, Ge Liu ... Qiping Feng
    A common genetic variant in Black patients increases the risk of renal disease, which increases the risk of sepsis, but there is no direct association between the variant and sepsis.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Time-varying and tissue-dependent effects of adiposity on leptin levels: A Mendelian randomization study

    Tom G Richardson, Genevieve M Leyden, George Davey Smith
    Leveraging time-varying and tissue-dependent genetic instruments into Mendelian randomization studies may help develop insight over more conventional applications.
    1. Immunology and Inflammation

    Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

    Eva Morgun, Jennifer Zhu ... Chyung-Ru Wang
    The bicontinuous nanospheres platform enables dual encapsulation and in vivo activation of lipid and protein antigen-specific T cells, resulting in enduring lipid depots for sustained immune responses.