Browse the latest research

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    1. Neuroscience

    Correlated spontaneous activity sets up multi-sensory integration in the developing higher-order cortex

    JaeAnn M Dwulet, Nawal Zabouri ... Julijana Gjorgjieva
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Linear antibody epitope prediction using AlphaFold2

    Jacob DeRoo, James S Terry ... Brian J Geiss
    AlphaFold2 can be used to accurately determine linear epitopes of antibodies with known heavy and light chain sequences.
    1. Neuroscience

    An applicable and efficient retrograde monosynaptic circuit mapping tool for larval zebrafish

    Tian-Lun Chen, Qiu-Sui Deng ... Xu-Fei Du
    An optimized rabies virus-based methodology enables efficient monosynaptic input mapping and circuit reconstruction from genetically defined neurons in larval zebrafish.
    1. Ecology
    2. Microbiology and Infectious Disease

    Environmental temperature is a strong driver of subspecies competition in the Drosophila microbiome

    Juan Bosco Gracia Alvira, Stefanie Migotti ... Christian Schlötterer
    Changes in abiotic factors, such as temperature, can affect the host fitness indirectly by modulating subspecies dynamics of key taxa, which are usually overlooked in microbiome research.
    1. Immunology and Inflammation

    DGKα and ζ deficiency causes regulatory T-cell dysregulation, destabilization, and conversion to pathogenic T-follicular helper cells to trigger IgG1-predominant autoimmunity

    Lei Li, Hongxiang Huang ... Xiao-Ping Zhong
    Diacylglycerol kinases (DGKs) α and ζ secure Treg stability, enforce CD28-dependence, and block conversion to pathogenic Tfh cells, safeguarding against autoimmune disease.
    1. Cell Biology

    Defective neuronal differentiation in Lowe syndrome is associated with mitochondrial dysfunction and impaired cilia-related Sonic Hedgehog signaling

    Grzegorz Walkiewicz, Siyu Chen ... Yang Sun
    OCRL deficiency is associated with mitochondrial dysfunction, altered ciliary signaling, and disrupted neural cell-state regulation across multiple experimental models of Lowe syndrome.
    1. Physics of Living Systems

    Intracellular mechanical fingerprint reveals cell type-specific mechanical differences

    Till M Muenker, Kerstin von Roden ... Timo Betz
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Plant Biology

    Improving rice drought tolerance through host-mediated microbiome selection

    Alex Styer, Dean Pettinga ... Devin Coleman-Derr
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    VDAC2 stabilizes a membrane-inserted, primed intermediate of BAX activation

    Varun Ravishankar, Laidy M Alvero-González ... Lucie Bergdoll
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology

    Loss of canonical sex steroid signaling correlates with prostate cancer progression and induces tumor escape in Drosophila

    Marine Vialat, Elissa Baabdaty ... Cyrille de Joussineau
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete