Browse the latest research

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    1. Biochemistry and Chemical Biology

    Concatenated Modular BK Channel Constructs Reveal Divergent Stoichiometry in Gating Control by LRRC26 (γ1), Pore, and Selectivity Filter

    Guanxing Chen, Qin Li ... Jiusheng Yan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Ecology
    2. Evolutionary Biology

    Fitness drivers of division of labor in vertebrates

    Irene García-Ruiz, Dustin Rubenstein
    Revised
    Reviewed Preprint v4
    Updated
    • Useful
    • Solid
    1. Neuroscience

    iGABASnFR2: Improved genetically encoded protein sensors of GABA

    Ilya Kolb, Jeremy P Hasseman ... Glenn C Turner
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Contributions of insula and superior temporal sulcus to interpersonal guilt and responsibility in social decisions

    Maria Gädeke, Tom Willems ... Johannes Schultz
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Massively parallel reporter assay for mapping gene-specific regulatory regions at single-nucleotide resolution

    Alastair J Tulloch, Ryan Nicholas Delgado ... Constance L Cepko
    Integrated locus-specific and mutational MPRAs reveal regulatory modules and nucleotide determinants governing cell type-specific gene expression, providing a scalable framework for mapping cis-regulatory architecture.
    1. Neuroscience

    Flexible neural representations of abstract structural knowledge in the human entorhinal cortex

    Shirley Mark, Philipp Schwartenbeck ... Timothy E Behrens
    A novel fMRI method reveals that humans generalize task structure across non-aligned state spaces, showing entorhinal representations support flexible knowledge transfer.
    1. Chromosomes and Gene Expression

    UV irradiation alters TFAM binding specificity and compaction of DNA

    Dillon E King, Emily E Beard ... Joel N Meyer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    RNA Selectively Modulates Activity of Virulent Amyloid PSMα3 and Host Defense LL-37 via Phase Separation and Aggregation Dynamics

    Bader Rayan, Eilon Barnea ... Meytal Landau
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Plant Biology

    The influence of heavy metal stress on the evolutionary transition of teosinte to maize

    Jonathan Acosta-Bayona, Miguel Vallebueno-Estrada, Jean-Philippe Vielle-Calzada
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology
    2. Neuroscience

    Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons

    Daniel Beaudet, Christopher L Berger, Adam G Hendricks
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Solid
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