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    1. Biochemistry and Chemical Biology

    A membrane-disruptive action of VBIT-4 challenges its role as a widely used VDAC1 oligomerization inhibitor

    Varun Ravishankar, Luís Borges-Araújo ... Lucie Bergdoll
    VBIT-4 perturbs lipid membranes without detectably affecting VDAC1 channels or oligomerization, calling for careful interpretation of its biological effects and highlighting the need to assess membrane interactions of hydrophobic compounds.
    1. Computational and Systems Biology

    Role of desolvation on biomolecular liquid–liquid phase separation

    Kai Zhang, Zhiyu Peng ... Wei Wang
    A desolvation-aware coarse-grained framework enables efficient and physically realistic modeling of biomolecular phase separation by capturing water-mediated effects on phase behavior, dense-phase packing, conformational reorganization, and dynamics.
    1. Microbiology and Infectious Disease

    The structural context of mutations in proteins predicts their effect on antibiotic resistance

    Anna G Green, Mahbuba Tasmin ... Maha Reda Farhat
    Spatial clustering of mutations in Mycobacterium tuberculosis proteins finds proteins that are involved in antibiotic resistance, and predicts which mutations cause resistance.
    1. Genetics and Genomics
    2. Neuroscience

    Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic signaling

    Saurabh Thapliyal, Parvathi Sushama Gopinath, Dominique A Glauser
    Nutritional state dynamically reshapes sensory processing to prioritize behavioral responses, revealing the plastic coupling of sensation, internal state, and behavior.
    1. Cancer Biology
    2. Evolutionary Biology

    Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

    Christopher J Graser, Wenbo Wu ... Franziska Michor
    Evolutionary modeling reveals that punctuated bursts of mutations facilitate fitness-valley crossing in cancer, promoting multi-step adaptation across complex fitness landscapes.
    1. Neuroscience

    Effects of nicotine compared to placebo gum on sensitivity to pain and mediating effects of peak alpha frequency

    Samantha K Millard, Alan KI Chiang ... David A Seminowicz
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Solid
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    RelB proximity proteomics and CRISPR screening define chromatin regulators of noncanonical NF-κB control of HIV latency and reactivation

    Cameron R Bussey-Sutton, Carley N Gray ... Brian D Strahl
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Deep anatomical and ultrastructural classification of neurons in the zebrafish olfactory bulb

    Nila R Mönig, Michał Januszewski ... Rainer W Friedrich
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Evidence for flexible regulation of movement and decision vigor in a reward-oriented task

    Adrien Conessa, Arnaud Boutin, Bastien Berret
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience

    Small circuit principles for learning in large worlds

    Dhruva V Raman, Christopher R Dunne ... Timothy O’Leary
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
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