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Page 6 of 1,856
    1. Neuroscience

    Modeling and simulation of neocortical micro- and mesocircuitry (Part I, anatomy)

    Michael W Reimann, Sirio Bolaños-Puchet ... Srikanth Ramaswamy
    A morphologically detailed model of brain region anatomy serves as the foundation for biophysically detailed simulations and provides insights into local and inter-regional connectivity.
    1. Chromosomes and Gene Expression

    ATAD2 mediates chromatin-bound histone chaperone turnover

    Ariadni Liakopoulou, Fayçal Boussouar ... Saadi Khochbin
    ATAD2 orchestrates histone turnover during spermatogenesis, regulating H3.3 deposition, chromatin condensation, and genome packaging to ensure proper sperm genome organization and transcriptional control.
    1. Stem Cells and Regenerative Medicine

    Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of osteoarthritis

    Nedaa Al-Jezani, Asmaa Affan ... Roman J Krawetz
    CD47Hi synovial mesenchymal stem cells are identified as a functionally distinct sub-population that regenerates articular cartilage and reduces osteoarthritis severity in a preclinical joint injury model.
    1. Neuroscience

    Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation)

    James B Isbister, Andras Ecker ... Michael W Reimann
    A general and open multiscale cortical model is presented which can be used by the community to study neural coding, spike sorting, plasticity, optogenetic and extracellular stimulation, local field potential, and electroencephalography.
    1. Cell Biology

    Cardiac neurons expressing a glucagon-like receptor mediate cardiac arrhythmia induced by high-fat diet in Drosophila

    Yunpo Zhao, Jianli Duan ... Zhe Han
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Incomplete
    1. Developmental Biology

    Progressive mural cell deficiencies across the lifespan in a foxf2 model of Cerebral Small Vessel Disease

    Merry Faye E Graff, Emma EM Heeg ... Sarah J Childs
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration

    Ravi Kumar, Simon Couly ... Ashish Lal
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Genetics and Genomics

    Reproducibility of Scientific Claims in Drosophila Immunity: A Retrospective Analysis of 400 Publications

    Hannah Westlake, Fabrice David ... Bruno Lemaitre
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

    Kexin Zhang, Timothy Grant, Nikolaus Grigorieff
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Genetics and Genomics

    A retrospective analysis of 400 publications reveals patterns of irreproducibility across an entire life sciences research field

    Joseph Lemaitre, Désirée Popelka ... Bruno Lemaitre
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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