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Sci-L3-Strand-seq uncovers sister chromatid exchange as a frequent hidden outcome of Cas9-induced breaks, revealing genome-editing consequences that are invisible to conventional sequencing, and can be associated with structural variations.

Co-folding methods accurately place and rank ligands within an optimization series, yet fail to separate true binders from docking false positives, suggesting complementary roles in drug discovery.

Low-frequency depression, an understudied form of synaptic plasticity, is proposed to reflect a reorganization of synaptic vesicles inside the readily releasable pool.

Resting-state MEG reveals a replicable, full-frequency profile of ageing that offers a foundation for comparing and validating brain health biomarkers although detecting specific effects requires careful consideration of statistical power.

Glutamine drives its own synthetase to assemble into inhibitory filaments, linking product concentration directly to a conformational switch that gates the active site.

Connectome-level analysis of the Drosophila neuroendocrine system reveals the organizational logic by which the brain integrates sensory information to regulate hormonal signaling.

Genetic and functional analyses identify SVEP1 as an extracellular matrix regulator that coordinates airway branching, smooth muscle differentiation, and alveolar maturation during lung development.