Browse the latest research

Page 6 of 1,901
    1. Structural Biology and Molecular Biophysics

    Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling

    Nevin K Zacharia, Stefanie Kuhns ... Esben Lorentzen
    The IFT172 C-terminus bridges IFT-A and IFT-B complexes through mutually exclusive interactions with IFT140 and IFT144, and harbors a U-box-like domain linking intraflagellar transport to ubiquitin-dependent ciliary signaling.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies

    Yi Lin, Benjamin Liou ... Ying Sun
    Human midbrain organoids provide a foundation for the development of patient-specific preclinical models to support personalized therapeutic approaches and enable evaluation of disease mechanisms and therapeutic strategies in human context.
    1. Neuroscience

    Dopamine ramps as a normative consequence of dual-process control

    Luke Priestley, Thomas Akam
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Evidence that humans underestimate body mass in microgravity: kinematic signatures in reaching movements during spaceflight

    Zhaoran Zhang, Yu Tian ... Kunlin Wei
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Genetics and Genomics

    Mutational and Expression Profile of ZNF217, ZNF750, ZNF703 Zinc Finger Genes in Kenyan Women Diagnosed with Breast Cancer

    Michael Kitoi, John Gitau ... Francis Makokha
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Distinct involvements of the subthalamic nucleus subpopulations in reward-biased decision-making in monkeys

    Kathryn Branam, Joshua I Gold, Long Ding
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation

    Uncovering the Heterogeneity and Ontogeny of Mouse Thymic Macrophages Reveals an Unexpected Early Checkpoint Role

    Helen Wang, Vinothkumar Rajan ... Juan Carlos Zúñiga-Pflücker
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Computational and Systems Biology

    TSvelo: Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription and splicing

    Jiachen Li, Zhe Wang ... Ye Yuan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology
    2. Neuroscience

    Transcriptional profiling of extraocular motor neurons reveals sim1a as a candidate strabismus-related gene

    Emily Gershowitz, Kyla Rose Hamling ... David Schoppik
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Decoding spine nanostructure in cultured neurons derived from mouse models of mental disorder reveals a schizophrenia-linked role for Ecrg4

    Yutaro Kashiwagi, Qingrui Liu ... Shigeo Okabe
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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