Browse the latest research

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    1. Neuroscience

    Perceiving animacy in ‘identical’ images

    Tal Boger, Chaz Firestone
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Continuous partitioning of neuronal variability

    Anuththara Rupasinghe, Adam S Charles, Jonathan W Pillow
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Exceptional
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition

    Natalie Gonzaga-Saavedra, Eleanor A Degen ... Shelby A Blythe
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Scale matters: Large language models with billions (rather than millions) of parameters better match neural representations of natural language

    Zhuoqiao Hong, Haocheng Wang ... Ariel Goldstein
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Heritability of movie-evoked brain activity and connectivity

    David C Gruskin, Daniel J Vieira ... Gaurav H Patel
    Genetic influences on how the brain processes complex naturalistic stimuli can be traced back to inherited control over stable spatial and temporal features of brain function.
    1. Stem Cells and Regenerative Medicine

    Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation

    Ellen Späth, Svenja C Schüler ... Alessandro Ori
    Leiomodin 1 acts as a critical molecular switch during early muscle stem cell differentiation by sequestering the deacetylase SIRT1 in the cytoplasm to initiate the myogenic program.
    1. Neuroscience

    Thalamo-accumbal circuit adaptations following extended oxycodone abstinence

    Yanaira Alonso Caraballo, Yan Li ... Elena Chartoff
    Prolonged oxycodone abstinence strengthens paraventricular thalamus to nucleus accumbens shell glutamatergic transmission in both sexes, yet only females show enhanced relapse, dissociating shared synaptic plasticity from sex-specific relapse vulnerability.
    1. Neuroscience

    Deletion of neuroligins from astrocytes does not detectably alter synapse numbers or astrocyte cytoarchitecture by maturity

    Samantha Rose Golf, Justin H Trotter ... Thomas C Südhof
    Genetic deletions in mouse models and human neuron co-cultures reveal that astrocytic neuroligins are dispensable for synapse formation and maintenance of normal astrocyte morphology, suggesting neuroligins serve alternative, unidentified roles.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Methylation clocks fail to generalize across genetically admixed individuals

    Sebastián Cruz-Gonzalez, Ogechukwu Okpala ... John A Capra
    DNA-methylation-based predictors of biological age often fail to generalize across human populations, limiting their utility as biomarkers of aging and disease.
    1. Neuroscience

    Pupil size reveals the perceptual quality and effortless nature of synesthesia

    Christoph Strauch, Casper Leenaars, Romke Rouw
    Synesthetes' pupils reflect the brightness of colors that they only see internally, making their hidden perceptual experience objectively measurable.
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