Browse the latest research

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    1. Structural Biology and Molecular Biophysics
    2. Physiology

    Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

    Giulia Arecchi, Marica Dente ... Chiara Tesi
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Neuroscience

    Modulating task outcome value to mitigate real-world procrastination via noninvasive brain stimulation

    Zhiyi Chen, Zhilin Ren ... Tingyong Feng
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Medicine
    2. Immunology and Inflammation

    TLR4 signaling drives tissue inflammation, Claudin-5 internalization, and vascular barrier breakdown in a mouse model of neonatal meningitis

    Philip V Seegren, Amir Rattner ... Jeremy Nathans
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Scale matters: Large language models with billions (rather than millions) of parameters better match neural representations of natural language

    Zhuoqiao Hong, Haocheng Wang ... Ariel Goldstein
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Stem Cells and Regenerative Medicine

    Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation

    Ellen Späth, Svenja C Schüler ... Alessandro Ori
    Leiomodin 1 acts as a critical molecular switch during early muscle stem cell differentiation by sequestering the deacetylase SIRT1 in the cytoplasm to initiate the myogenic program.
    1. Neuroscience

    Concurrent category-selective neural activity across the ventral occipito-temporal cortex supports a non-hierarchical view of human visual recognition

    Corentin Jacques, Jacques Jonas ... Bruno Rossion
    Face-selective neural activity occurs concurrently across the human ventral occipito-temporal cortex, challenging traditional hierarchical models of visual object recognition where response latencies increase along the cortical hierarchy.
    1. Cell Biology

    Analysis of cancer mutations introduced into the Drosophila melanogaster Notch negative regulatory region uncovers a diversity of regulatory outcomes

    Hideyuki Shimizu, Martin Baron
    Heterogeneity in outcomes of differently located activating mutations of Notch indicates the need and potential for mutant specific targeting of Notch in cancer.
    1. Neuroscience

    In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila

    Madeline P Marques, Bo Sun ... Hongjie Li
    In-situ glial cell-surface proteomics reveals DIP-β as a glial longevity factor that enhances intercellular communication and extends lifespan in aging Drosophila.
    1. Neuroscience

    Heritability of movie-evoked brain activity and connectivity

    David C Gruskin, Daniel J Vieira ... Gaurav H Patel
    Genetic influences on how the brain processes complex naturalistic stimuli can be traced back to inherited control over stable spatial and temporal features of brain function.
    1. Neuroscience

    Deletion of neuroligins from astrocytes does not detectably alter synapse numbers or astrocyte cytoarchitecture by maturity

    Samantha Rose Golf, Justin H Trotter ... Thomas C Südhof
    Genetic deletions in mouse models and human neuron co-cultures reveal that astrocytic neuroligins are dispensable for synapse formation and maintenance of normal astrocyte morphology, suggesting neuroligins serve alternative, unidentified roles.
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