Peptide inhibitors of E3 ubiquitin ligase anaphase-promoting complex/cyclosome, engineered for enhanced affinity by incorporating unnatural amino acids, are able to block substrate ubiquitination and drive degradation of a fused target.
Environmental chloride ions act as essential counterions that enable coral opsins to respond to visible light, and the polar residue Glu292 plays a critical role in chloride binding.
A novel point assignment method achieves 80% f1-score in single-neuron reconstruction across broad brain regions, enabling high-throughput brain-wide projection mapping.
Lee R Berger, Tebogo Vincent Makhubela ... John Hawks
Remains of the extinct hominin species Homo naledi were interred by members of their own species, the first time that burial has been documented in populations other than modern humans and Neanderthals.
