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    1. Neuroscience

    Relative timescale of channel voltage dependence and channel density regulation impacts assembly and recovery of activity

    Yugarshi Mondal, Ronald L Calabrese, Eve Marder
    Ion channel voltage-dependence alterations can shape intrinsic homeostatic plasticity, even if operating faster than other intrinsic regulatory processes—where timescale separation would suggest its influence should be negligible.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

    Soumajit Dutta, Diwakar Shukla
    New psychoactive substances activate cannabinoid receptors using distinct ligand-receptor interactions.
    1. Cell Biology

    Distinct functions of cardiac β-adrenergic receptors in the T-tubule vs. outer surface membrane

    George WP Madders, Marion Barthé ... Rodolphe Fischmeister
    A size exclusion strategy using PEGylation of isoprenaline allowed to demonstrate that cardiac β-adrenergic receptors located in the outer surface membrane control mainly cAMP/PKA in the cytosol while those located in the T-tubule membrane control cAMP/PKA in the nucleus.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations

    Gabriel Monteiro da Silva, Kyle Lam ... Brenda M Rubenstein
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Conduction pathway for potassium through the E. coli pump KdpFABC

    Adel Hussein, Xihui Zhang ... David L Stokes
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation

    Takashi Hotta, Morgan L Pimm ... Kristen J Verhey
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Microbiology and Infectious Disease

    Research advance: Unexpected plasticity in the life cycle of Trypanosoma brucei

    Carina Praisler, Jaime N Lisack ... Markus Engstler
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Medicine

    Addressing cultural and knowledge barriers to enable preclinical sex inclusive research

    Brianna N Gaskill, Benjamin Phillips ... Natasha A Karp
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Human EEG and artificial neural networks reveal disentangled representations and processing timelines of object real-world size and depth in natural images

    Zitong Lu, Julie D Golomb
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Region-specific mechanosensation controls Drosophila postural control behaviour

    William Roseby, Jonathan AC Menzies ... Claudio R Alonso
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
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