Browse the latest research

Page 6 of 1,870
    1. Immunology and Inflammation

    Contrasting roles for IKK regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive 𝛄δ T cells

    Farjana Islam, Cayman Williams ... Benedict Seddon
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

    Conor J Howard, Nathan S Abell ... Diane E Dickel
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cell Biology

    A high-throughput assay for the measurement of Ca2+-oscillations and insulin release from uniformly sized β-cell spheroids

    Stijn Robben, Patricia Davidson ... Thomas Voets
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Evolutionary Biology

    Earliest Evidence of Elephant Butchery at Olduvai Gorge (Tanzania) Reveals the Evolutionary Impact of Early Human Megafaunal Exploitation

    Manuel Domínguez-Rodrigo, Enrique Baquedano ... Audax Mabulla
    Revised
    Reviewed Preprint v4
    Updated
    • Valuable
    • Incomplete
    1. Neuroscience

    Material Damage to Multielectrode Arrays after Electrolytic Lesioning is in the Noise

    Alice Tor, Stephen E Clarke ... Brain Interfacing Laboratory
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Neuroscience

    Adjoint propagation of error signal through modular recurrent neural networks for biologically plausible learning

    Zhuo Liu, Hao Shu ... Tao Chen
    The adjoint propagation framework enables the concurrent flow of signals and errors, providing a biologically and physically plausible learning mechanism.
    1. Chromosomes and Gene Expression

    Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites

    Yatendra Kumar, Dipta Sengupta ... Wendy A Bickmore
    Acetylation of histone H3 at the nucleosome surface is associated with destabilised nucleosomes and is a useful new functional genomics mark for identifying regulatory regions of the mammalian genome.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Correction: Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish

    Mounir El Maï, Marta Marzullo ... Miguel Godinho Ferreira
    1. Cell Biology

    SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy

    Grace Essuman, Midhat Rizvi ... Emmanuelle Cordat
    Distal renal tubular acidosis induced by some SLC4A1 variants is characterized by cytosolic pH alkalization, reduced ATP synthesis and defective autophagy degradative flux.
    1. Computational and Systems Biology

    Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

    Zhiwei Huang, Songhao Luo ... Jiajun Zhang
    DNA damage reshapes genome-wide transcriptional bursting, with distinct burst size and frequency programs associated with differentiation, apoptosis, and survival decisions.
Newer Older