Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the bicarbonate receptor GPR30

    Shota Kaneda, Airi Jo-Watanabe ... Osamu Nureki
    Cryo-electron microscopy structure of human G-protein-coupled receptor 30 in the presence of bicarbonate ions revealed unique extracellular pockets and critical residues for bicarbonate binding and activation.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases

    Binnu Gangadharan, Daniel L Kober, Luke M Rice
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Investigation of Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis

    Marie Shimogawa, Ming-Hao Li ... E James Petersson
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1

    Jill von Velsen, Pauline Juyoux ... Matthew W Bowler
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Characterization of an early-diverging KCNE potassium-channel auxiliary subunit in the jawless vertebrate lamprey

    Go Kasuya, Kaei Ryu ... Koichi Nakajo
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    A membrane insertion code for intrinsically disordered proteins

    Fidha Nazreen Kunnath Muhammedkutty, Huan-Xiang Zhou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Physiology

    Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

    Giulia Arecchi, Marica Dente ... Chiara Tesi
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    ATP-driven conformational dynamics reveal hidden intermediates in a heterodimeric ABC transporter

    Matija Pečak, Christoph Nocker, Robert Tampé
    Hidden outward-facing intermediates and long-lived ATP-bound states reveal how ATP binding drives conformational dynamics in the heterodimeric ABC transporter TmrAB.
    1. Structural Biology and Molecular Biophysics

    Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

    Kexin Zhang, Timothy Grant, Nikolaus Grigorieff
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Optimising the tilt-increment for in situ cryo-electron tomography

    Maarten W Tuijtel, Tomáš Majtner ... Martin Beck
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
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Highlights

    1. Structural Biology and Molecular Biophysics

    Glycobiology: How enzymes make the right choice during biosynthesis

    Ana S Ramírez, Camilo Perez
    1. Structural Biology and Molecular Biophysics

    Membrane Biology: Two binding sites are better than one

    Mackenzie K Scott, John E Burke
    1. Structural Biology and Molecular Biophysics

    Membrane Proteins: A missing link for efflux pumps

    Hilal Wehbi, Isabelle Broutin

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Felix Campelo
    Pompeu Fabra University, Spain
  3. Qiang Cui
    Boston University, United States
  4. See more editors