Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

    Kexin Zhang, Timothy Grant, Nikolaus Grigorieff
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis

    Ivana Petrovic, Samit Desai ... Stephan Grzesiek
    Formation and stability of endocytic receptor-arrestin complexes during clathrin-mediated endocytosis are governed by phosphorylation-dependent arrestin-AP2 interactions.
    1. Structural Biology and Molecular Biophysics

    Allosteric effects of the coupling cation in melibiose transporter MelB

    Parameswaran Hariharan, Yuqi Shi ... Lan Guan
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation

    Takashi Hotta, Morgan L Pimm ... Kristen J Verhey
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Functionally coupled ion channels begin co-assembling at the start of their synthesis

    Roya Pournejati, Jessica M Huang ... Oscar Vivas
    BK and CaV1.3 channels interact early during biogenesis, assembling intracellularly before membrane localization, indicating coordinated processes for functional coupling.
    1. Structural Biology and Molecular Biophysics

    Insights from aquaporin structures into drug-resistant sleeping sickness

    Modestas Matusevicius, Robin A Corey ... Simone Weyand
    Cryo-EM structures of human aquaporin AQP2 bound to the anti-trypanosomal drugs pentamidine and melarsoprol identify the molecular mechanism for drug-resistant sleeping sickness.
    1. Structural Biology and Molecular Biophysics

    Conformational Variability of HIV-1 Env Trimer and Viral Vulnerability

    Yiwei Cao, Wonpil Im
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Enhanced Processivity and Collective Force Production of Kinesin-1 at Low Radial Forces

    Andrew M Hensley, Ahmet Yildiz
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Short activation domains control chromatin association of transcription factors

    Vinson B Fan, Abrar A Abidi ... Max V Staller
    Single-molecule tracking of transcription factors in living cells revealed how mutations that make short activation domains stronger increased the fraction of transcription factor molecules bound to chromatin and led to longer residence times on chromatin.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy

    Liudmyla Arifova, Brian S MacTavish ... Douglas J Kojetin
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu
    1. Structural Biology and Molecular Biophysics

    Same structure, different mechanisms?

    Francis TF Tsai, Christopher P Hill

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Felix Campelo
    Pompeu Fabra University, Spain
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
  4. See more editors