Immunology and Inflammation

Latest articles

1. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B

   Ozkan Aydemir, Jeffrey A Bailey ... TEDDY Study Group

   HLA-DRA intronic haplotype associates with opposite effects on type 1 diabetes and celiac disease, refining genetic risk prediction and implicating complement genes C4A and C4B in divergent autoimmune pathways.
2. 1. Immunology and Inflammation

   Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco-flavored e-cigarette-exposed mouse lungs

   Gagandeep Kaur, Thomas Lamb ... Irfan Rahman

   Profiling cell-specific immune responses reveals altered neutrophil function and enhanced T-cell mediated cell death following acute in vivo exposure to tobacco-flavored e-cigarette aerosol using single-cell technology.
3. 1. Immunology and Inflammation
   2. Neuroscience

   Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi–Goutières syndrome neuropathology

   Kelsey M Nemec, Genevieve Uy ... F Chris Bennett

   A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive interferon responses.
4. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir

   Pien Margien van Paassen, Alexander O Pasternak ... Godelieve J de Bree

   In individuals who started antiretroviral therapy during acute HIV infection, the proliferative capacity of HIV-specific CD8+ T-cells at 24 weeks of therapy predicted the subsequent reduction in the viral reservoir.
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Doubling dolutegravir dosage reduces the viral reservoir in ART-treated people with HIV

   Céline Fombellida-Lopez, Aurelija Valaitienė ... Gilles Darcis

   In a randomized trial, ART intensification by doubling the dolutegravir dosage in people with HIV stably suppressed on dolutegravir-based ART reduced levels of four HIV reservoir markers in peripheral blood.
6. 1. Immunology and Inflammation

   Western lifestyle linked to maladaptive trained immunity

   Aurelia Josephine Merbecks, Christabel Mennicken ... Eicke Latz

   Trained immunity enhances innate immune responses, yet a Western lifestyle may lead to maladaptive trained immunity and drive non-communicable diseases.
7. 1. Immunology and Inflammation
   2. Neuroscience

   Trained immunity in acute and chronic neurological diseases

   Sijia Zhang, Arthur Liesz

   Trained immunity provides a unifying framework linking innate immune memory to both protective and maladaptive inflammation across neurological diseases, offering new insights into disease mechanisms and potential therapeutic strategies.
8. 1. Chromosomes and Gene Expression
   2. Immunology and Inflammation

   The long non-coding RNA Dreg1 is required for optimal ILC2 development

   Sara Quon, Adelynn Tang ... Rhys S Allan
9. 1. Medicine
   2. Immunology and Inflammation

   PDL-1+ Neutrophils mediate susceptibility during endotoxemia in Metabolically Dysfunctional-Associated Fatty Liver Disease

   Cleyson da Cruz Oliveira Barros, Alexandre Kanashiro ... Fernando Queiroz Cunha
10. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

    Long-Feng Lu, Can Zhang ... Shun Li

    CDK2-mediated TBK1 degradation via Dtx4 represents a previously unrecognized regulatory mechanism that modulates antiviral immunity in fish.