Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation

    Simplifying principles underlying the highly complex peptide motif of the promiscuous chicken MHC class I molecule, BF2*21:01

    Michael Harrison, Paul E Chappell ... Jim Kaufman
    Infectious disease resistance in chickens strongly depends on a genomic region called the MHC, and the rules governing pathogen peptide presentation for a key MHC molecule may aid vaccine development.
    1. Immunology and Inflammation

    Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signaling

    Sung Hoon Cho, Shawna K Brookens ... Mark R Boothby
    Genetic and biochemical analyses reveal a way to overcome the metabolic flexibility of B cells and undermine their cytokine receptor signaling and differentiation into antibody-secreting cells, therapeutic targets in systemic lupus erythematosus (SLE).
    1. Immunology and Inflammation

    ITK deficiency protects against autoimmune pulmonary hemorrhage by promoting Amphiregulin-producing regulatory T cells

    Mohammad Saddam Hossain, Ali Mobeen ... Mobin Karimi
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Immunology and Inflammation

    Cell junction disruption drives translocation of gasdermin A and gasdermin B from cytoskeleton to plasma membrane during acantholysis

    Kidong Kang, Ying Wang, Edward A Miao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C

    Cilia R Pothast, Ian Derksen ... Ferenc A Scheeren
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Convincing
    1. Immunology and Inflammation

    An IL-21R STAT hypomorph circumvents functional redundancy in germinal centre responses

    Christoph Jandl, Joanna Warren ... Cecile King
    An IL-21 receptor mutation that differentially regulates STAT1 and STAT3 activation influenced the differentiation of T follicular cells.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    GM-CSF regulates conserved ILC-like transcriptional states and myeloid cell signaling during ulceration in Crohn’s disease

    Joshua K Morrison, Ksenija Sabic ... Ling-shiang Chuang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Immunology and Inflammation

    Role of gut epithelial-cell derived transglutaminase 2 in the formation of celiac disease autoantibodies

    Runa I Løberg, Helena A Abdi-Dezfuli ... M Fleur du Pré
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Immunology and Inflammation

    Syntaxin11 deficiency inhibits CRAC channel priming to suppress cytotoxicity and gene expression in T lymphocytes independent of membrane trafficking

    Sritama Datta, Abhikarsh Gupta ... Monika Vig
    Syntaxin11 directly controls a novel step in the activation of calcium channels, which helps activate genes and kill infected cells by a process distinct from moving cargo inside cells.
    1. Immunology and Inflammation

    Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses

    Yujie Fang, Zihan Guan ... Ke Peng
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
Load more

Highlights

    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Antibody Language Models: Taking the biology seriously makes models better

    Antonio Matas-Gil, Andreas Tiffeau-Mayer
    1. Immunology and Inflammation
    2. Neuroscience

    Microglia: Replacing the immune system of the brain

    Julie Rebejac, Soyon Hong

Senior editors

  1. Diane M Harper
    University of Michigan, United States
  2. Satyajit Rath
    National Institute of Immunology, New Delhi, India
  3. Tadatsugu Taniguchi
    Tadatsugu Taniguchi
    Research Center for Advanced Science and Technology, The University of Tokyo, Japan
  4. See more editors