Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

   Peter Georgiev, Sheila Johnson ... Arlene H Sharpe

   A comprehensive investigation of extracellular asparagine utilization highlights its role as a critical regulator of murine CD4+ T cell activation, differentiation, and function.
2. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Celldetective, an AI-enhanced image analysis tool for unraveling dynamic cell interactions

   Rémy Torro, Beatriz Díaz-Bello ... Laurent Limozin

   Celldetective is an open-source software integrating segmentation, tracking, and event detection to perform high-throughput end-to-end study of dynamic cell interactions, without requiring coding skills, demonstrated on microscopy immunological assays.
3. 1. Immunology and Inflammation
   2. Neuroscience

   Cribriform plate microenvironment assembles a suppressive myeloid network during EAE-induced neuroinflammation

   Collin Laaker, Martin Hsu ... Zsuzsanna Fabry

   Regulatory immune cells accumulate at the nose-to-brain interface during neuroinflammation, potentially dampening damaging immune responses.
4. 1. Immunology and Inflammation

   TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy

   Josselyn D Barahona, Liping Yang ... Wayne M Yokoyama

   Uterine natural killer (NK) cells require TGF-β to be derived from conventional NK cells and contribute to successful pregnancy.
5. 1. Immunology and Inflammation

   Application of Engineered NK-92 Cell Extracellular Vesicles in the Treatment of Systemic Lupus Erythematosus

   Yu Sun, Zeyu Tang ... Xiaowei Dou
6. 1. Cell Biology
   2. Immunology and Inflammation

   Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses during inflammation

   Priyanka Gajwani, Li Wang ... Jalees Rehman
7. 1. Immunology and Inflammation
   2. Cancer Biology

   Integrin-deficient T cell leukemia accumulates in the central nervous system

   Samantha Y Lux, Cynthia Chen ... Susan R Schwab
8. 1. Medicine
   2. Immunology and Inflammation

   A surviving beta cell subpopulation enriched in patients with T1D

   Maxwell Spurrell, John S Tsang, Kevan C Herold
9. 1. Immunology and Inflammation

   Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation

   Christopher Zhe Wei Lee, Farah Tasnim ... Florent Ginhoux

   Co-culturing pluripotent stem cell-derived hepatocytes and macrophages establishes a physiologically relevant liver model that captures macrophage–hepatocyte interactions, significantly improves hepatocyte maturation, and enables more accurate prediction of immune-mediated drug toxicity.
10. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Correlates of protection against African swine fever virus identified by a systems immunology approach

    Kirill Lotonin, Francisco Brito ... Artur Summerfield

    Dissecting protective versus detrimental immune responses uncovers biomarkers and mechanisms that can inform the rational design and evaluation of live attenuated vaccines against African swine fever virus.