Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation
    2. Cancer Biology

    Single-cell characterization of tumor immune landscapes in colorectal cancer humanized mice

    Sanne Bootsma, Job Saris ... Louis Vermeulen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Immunology and Inflammation

    FoxO factors preserve airway epithelial homeostasis by coordinating adaptive stress responses

    Karin Uliczka, Judith Bossen ... Thomas Roeder
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Immunology and Inflammation

    Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensis

    Weilun Guo, Shruti S Apte ... Jörn Coers
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Immunology and Inflammation
    2. Cancer Biology

    Spatial Compartmentalization of TCR Repertoires Between Primary Melanomas and Sentinel Lymph Nodes Reveals Distinct Clonal Architectures and Shared Antigen Recognition

    Simo Kitanovski, Nalini Srinivas ... Jürgen C Becker
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Immunology and Inflammation

    Mouse models with human antibody repertoires for inducing multiple lineages of HIV-1 broadly neutralizing antibodies

    Ming Tian, Hwei-Ling Cheng ... Frederick W Alt
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Immunology and Inflammation

    Simplifying principles underlying the highly complex peptide motif of the promiscuous chicken MHC class I molecule, BF2*21:01

    Michael Harrison, Paul E Chappell ... Jim Kaufman
    Infectious disease resistance in chickens strongly depends on a genomic region called the MHC, and the rules governing pathogen peptide presentation for a key MHC molecule may aid vaccine development.
    1. Immunology and Inflammation

    Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signaling

    Sung Hoon Cho, Shawna K Brookens ... Mark R Boothby
    Genetic and biochemical analyses reveal a way to overcome the metabolic flexibility of B cells and undermine their cytokine receptor signaling and differentiation into antibody-secreting cells, therapeutic targets in systemic lupus erythematosus (SLE).
    1. Immunology and Inflammation

    ITK deficiency protects against autoimmune pulmonary hemorrhage by promoting Amphiregulin-producing regulatory T cells

    Mohammad Saddam Hossain, Ali Mobeen ... Mobin Karimi
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Immunology and Inflammation

    Cell junction disruption drives translocation of gasdermin A and gasdermin B from cytoskeleton to plasma membrane during acantholysis

    Kidong Kang, Ying Wang, Edward A Miao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C

    Cilia R Pothast, Ian Derksen ... Ferenc A Scheeren
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Convincing
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Highlights

    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Antibody Language Models: Taking the biology seriously makes models better

    Antonio Matas-Gil, Andreas Tiffeau-Mayer
    1. Immunology and Inflammation
    2. Neuroscience

    Microglia: Replacing the immune system of the brain

    Julie Rebejac, Soyon Hong

Senior editors

  1. Wendy S Garrett
    Wendy S Garrett
    Harvard T.H. Chan School of Public Health, United States
  2. Tony Ng
    King's College London, United Kingdom
  3. Joshua T Schiffer
    Fred Hutchinson Cancer Research Center, United States
  4. See more editors