Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Recording the spiking activity of muscle fibers at high resolution in awake, behaving mice, reveals that locomotor speed is driven by highly variable subsets of motor units.
Md Zubayer Hossain Saad, William G Ryan ... Bruce A Bamber
An odorant is encoded in the periphery as independent inputs of attractive and repulsive valence, which are then integrated and balanced to drive overall chemotactic behavior.
Naturally occurring bacterial endosymbionts can modify population growth, crop damage, and dispersal in the Russian wheat aphid, a major pest of cereal crops, highlighting their potential for sustainable pest management.
Marc E Normandin, Pedro M Ogallar ... Isabel A Muzzio
Stable and dynamic prelimbic neurons preserve threat-generalization gradients despite ensemble turnover, supporting enduring representations of stimulus significance rather than freezing.
Kristopher T Jensen, Peter T Doohan ... Timothy E Behrens
Recently discovered sequence representations in prefrontal cortex can be combined with the ubiquitous principle of neural attractor dynamics to support planning in complex environments.
Violations of strong memory-based predictions trigger a cascade of changes in cognitive control, attention, and arousal, with differential impacts on the encoding of unexpected information into memory.
Jitendra Kumar, Shravan K Uppulapu ... Santosh Kumar
SUMO2ylation of redox protein p66Shc drives endothelial dysfunction by promoting oxidative stress, identifying a potential therapeutic target for cardiovascular disease.
Human forebrain organoids reveal that amyloid-driven microglia recruit killer T cells via CCL5, forming a self-amplifying neuroinflammatory loop targetable by CCR5 or CXCR3 blockade.
In mammalian neocortex, opposing Krüppel-like factor (KLF) transcription factors first activate and then repress a genetic program related to axon outgrowth, potentially contributing to loss of cortical axon outgrowth in the adult.
Syntaxin11 directly controls a novel step in the activation of calcium channels, which helps activate genes and kill infected cells by a process distinct from moving cargo inside cells.
