Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Conan JO O'Brien, Giorgio Ratti ... Ana I Domingos
Loss of class A scavenger receptor MARCO results in elevated lung Ace expression and elevated plasma aldosterone concentrations in male mice, demonstrating an endocrine function of this immune scavenger receptor.
Alina Xiaoyu Yang, Lisa Ramos-Rodriguez ... Yang Zhou
PLSCR1 is an IFN-λ-stimulated gene that enhances IFN-λR1 expression at both transcriptional and protein level, highlighting the potential for targeting PLSCR1 pathways in anti-influenza therapy.
Louis Richevaux, Dongkyun Lim ... Desdemona Fricker
Nonlinear dendritic integration in single presubicular neurons provides a mechanism for combining vestibular-based head-direction signals and visual landmark signals to anchor the brain’s internal compass.
A combination of viral strategies, electrophysiological methods, and behavioral tests reveals how GPR30 in spinal CCK+ neurons modulates neuropathic pain.
In mice, loss of TGF-beta signaling specifically in vascular endothelial cells leads to retinal hypovascularization, choroidal neovascularization, a pro-inflammatory state within brain and retinal endothelial cells, and an influx of diverse inflammatory cells into the retina.
Stephen A Banse, Christine A Sedore ... Patrick C Phillips
Computer screening identifies that the widely prescribed vitamin A derivative all-trans retinoic acid increases both longevity and late-life health in a powerful genetic model system.
Transposon sequencing analyses reveal that among genomically diverse clinical Mycobacterium intracellulare strains and the type strain, 131 genes were comprehensively identified as universal essential genes suggesting promising drug targets.
