Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Ecology
    2. Physics of Living Systems

    The dominant–egalitarian transition in species-rich communities

    David A Kessler, Nadav M Shnerb
    A model of a species-rich neutral ecosystem, perturbed by environmental noise impacting each species differently, predicts that for large noise the community is dominated by a few species, while for weaker noise it is more egalitarian, with many significant species.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    HIF1A-mediated pathways promote euploid cell survival in chromosomally mosaic embryos

    Estefania Sanchez-Vasquez, Marianne E Bronner, Magdalena Zernicka-Goetz
    Aneuploid mosaic mouse embryos require hypoxia for survival, and understanding these pathways may inform new strategies to support embryo viability.
    1. Neuroscience

    Homeostatic synaptic plasticity of miniature excitatory postsynaptic currents in mouse cortical cultures requires neuronal Rab3a

    Andrew G Koesters, Mark M Rich, Kathrin Engisch
    The first demonstration that a protein thought to function presynaptically (Rab3a) is required for homeostatic, activity-dependent synaptic plasticity of quantal size in central neurons.
    1. Neuroscience

    Age and learning shapes sound representations in auditory cortex during adolescence

    Benedikt Praegel, Feng Chen ... Adi Mizrahi
    Weaker performance in adolescent mice arises from immature cortical representations and cognitive bias, linking developmental changes in behavior with underlying neural coding.
    1. Neuroscience

    Synchronous ensembles of hippocampal CA1 pyramidal neurons during novel exploration

    En-Li Chen, Tsai-Wen Chen ... Bei-Jung Lin
    CA1 pyramidal neurons exhibit synchronous spiking during movement and pauses in novel environments, reflecting a neural signature of spatial learning.
    1. Cancer Biology

    KDM5 demethylases suppress R-loop-mediated ‘viral mimicry’ and DNA damage in breast cancer cells

    Lena Lau, Kurt Henderson ... Marie Classon
    KDM5 inhibition/disruption selectively induces R-loop-mediated DNA damage and innate immune activation in breast cancer cells, while sparing normal cells, unveiling a tumor-specific therapeutic vulnerability with broad translational potential.
    1. Neuroscience

    Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness

    Guylaine Hoffner, Pablo Castro ... Béchir Jarraya
    The effects of transcranial direct current stimulation on cortical dynamics depend on the state of consciousness and the stimulation polarity.
    1. Neuroscience

    Shared functional organization between pulvinar-cortical and cortico-cortical connectivity and its structural and molecular imaging correlates

    Gianpaolo Antonio Basile, Augusto Ielo ... Alberto Cacciola
    The pulvinar complex harbors multiple representations of cortico-cortical connectivity organized hierarchically across its ventro-dorsal and medio-lateral axes.
    1. Epidemiology and Global Health

    Forecasting the spatial spread of an Ebola epidemic in real time: Comparing predictions of mathematical models and experts

    James D Munday, Alicia Rosello ... Sebastian Funk
    Models were more consistent than individual experts but performed comparably to ensembles of many experts and relative performance varied by month, justifying the use of combined model and expert forecast methodologies.
    1. Cancer Biology
    2. Evolutionary Biology

    Cancer–immune coevolution dictated by antigenic mutation accumulation

    Long Wang, Christo Morison, Weini Huang
    Genetic information in cancer cells reveals the strength of cancer–immune interactions in an individual-based stochastic model, which captures explicit interactions between cancer and effector cells.