Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Age and learning shapes sound representations in auditory cortex during adolescence

    Benedikt Praegel, Feng Chen ... Adi Mizrahi
    Weaker performance in adolescent mice arises from immature cortical representations and cognitive bias, linking developmental changes in behavior with underlying neural coding.
    1. Neuroscience

    Synchronous ensembles of hippocampal CA1 pyramidal neurons during novel exploration

    En-Li Chen, Tsai-Wen Chen ... Bei-Jung Lin
    CA1 pyramidal neurons exhibit synchronous spiking during movement and pauses in novel environments, reflecting a neural signature of spatial learning.
    1. Neuroscience

    Shared functional organization between pulvinar-cortical and cortico-cortical connectivity and its structural and molecular imaging correlates

    Gianpaolo Antonio Basile, Augusto Ielo ... Alberto Cacciola
    The pulvinar complex harbors multiple representations of cortico-cortical connectivity organized hierarchically across its ventro-dorsal and medio-lateral axes.
    1. Cancer Biology

    KDM5 demethylases suppress R-loop-mediated ‘viral mimicry’ and DNA damage in breast cancer cells

    Lena Lau, Kurt Henderson ... Marie Classon
    KDM5 inhibition/disruption selectively induces R-loop-mediated DNA damage and innate immune activation in breast cancer cells, while sparing normal cells, unveiling a tumor-specific therapeutic vulnerability with broad translational potential.
    1. Neuroscience

    Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness

    Guylaine Hoffner, Pablo Castro ... Béchir Jarraya
    The effects of transcranial direct current stimulation on cortical dynamics depend on the state of consciousness and the stimulation polarity.
    1. Cancer Biology
    2. Evolutionary Biology

    Cancer–immune coevolution dictated by antigenic mutation accumulation

    Long Wang, Christo Morison, Weini Huang
    Genetic information in cancer cells reveals the strength of cancer–immune interactions in an individual-based stochastic model, which captures explicit interactions between cancer and effector cells.
    1. Cell Biology
    2. Developmental Biology

    Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL

    Dong Luo, Jing Zheng ... Xinjun Zhang
    RSPO-ZNRF3/RNF43 specifically regulates the degradation of FZD5/8 under Wnt stimulation independently of DVL.
    1. Epidemiology and Global Health

    Forecasting the spatial spread of an Ebola epidemic in real time: Comparing predictions of mathematical models and experts

    James D Munday, Alicia Rosello ... Sebastian Funk
    Models were more consistent than individual experts but performed comparably to ensembles of many experts and relative performance varied by month, justifying the use of combined model and expert forecast methodologies.
    1. Ecology

    Partitioning changes in ecosystem productivity by effects of species interactions in biodiversity experiments

    Jing Tao, Charles A Nock ... Ji Zheng
    A novel approach has been developed to partition the net biodiversity effect into components associated with positive, negative, and competitive species interactions.
    1. Neuroscience

    Diffusion MRS tracks distinct trajectories of neuronal development in the cerebellum and thalamus of rat neonates

    Clémence Ligneul, Lily Qiu ... Jason P Lerch
    Diffusion-weighted magnetic resonance spectroscopy and microstructural modelling longitudinally tracks cell-specific cerebellar development to non-invasively monitor, and better understand, early brain microstructure.