Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Heterogeneous associations of polygenic indices of 35 traits with mortality: a register-linked population-based follow-up study

    Hannu Lahtinen, Jaakko Kaprio ... Pekka Martikainen
    Polygenic indices related to the best-established social, psychological, and behavioural mortality risk phenotypes had the strongest associations with mortality.
    1. Neuroscience

    Progressive overfilling of readily releasable pool underlies short-term facilitation at recurrent excitatory synapses in layer 2/3 of the rat prefrontal cortex

    Jiwoo Shin, Seung Yeon Lee ... Suk-Ho Lee
    Excitatory recurrent synapses in the upper pyramidal layer of the prefrontal cortex exhibit delayed short-term facilitation, despite very high vesicular fusion probability, through synaptotagmin 7-dependent overfilling of release sites.
    1. Neuroscience

    Compressed sensing-based approach identifies modular neural circuitry driving learned pathogen avoidance

    Timothy Hallacy, Abdullah Yonar ... Sharad Ramanathan
    An efficient neural screening approach rapidly identifies circuit modules governing distinct behavioral transitions in response to pathogen exposure.
    1. Neuroscience

    Backward conditioning reveals flexibility in infralimbic cortex inhibitory memories

    Nura W Lingawi, Billy Chieng ... Vincent Laurent
    Optogenetic stimulation of the infralimbic cortex reveals properties of local inhibitory memories.
    1. Neuroscience

    Sex peptide targets distinct higher order processing neurons in the brain to induce the female post-mating response

    Mohanakarthik P Nallasivan, Deepanshu ND Singh ... Matthias Soller
    Sex peptide response-inducing neurons (SPRINz) in the central brain can induce female post-mating responses through sex peptide received by mating.
    1. Neuroscience

    Sense of control buffers against stress

    Jennifer C Fielder, Jinyu Shi ... Nikolaus Steinbeis
    A novel behavioural task that measures and manipulates subjective control in humans reveals that experimentally heightened feelings of control buffer against the negative impact of subsequent stress.
    1. Developmental Biology

    map3k1 is required for spatial restriction of progenitor differentiation in planarians

    Bryanna Isela-Inez Canales, Hunter O King, Peter W Reddien
    map3k1 inhibits progenitor differentiation until suitable positional cues are acquired as a mechanism of pattern formation.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation

    Takashi Hotta, Morgan L Pimm ... Kristen J Verhey
    Three newly developed biosensors demonstrate that the C-terminal tail of α-tubulin does not freely extend from the microtubule surface as widely thought, but rather is inaccessible along most microtubules in cells.
    1. Developmental Biology

    Mouse skeletal muscle satellite cells co-opt the tenogenic gene Scleraxis to instruct regeneration

    Yun Bai, Tyler Harvey ... Chen-Ming Fan
    Muscle stem cells repurpose the tenogenic factor Scx to establish a muscle-specific transcriptional program that sustains stem cell expansion, migration, differentiation, fusion, self-renewal, and survival.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs

    Fangyuan Dong, Shan Zhang ... Shu-Heng Jiang
    Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8+ T cell immunity.