Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Experience transforms crossmodal object representations in the anterior temporal lobes

    Aedan Yue Li, Natalia Ladyka-Wojcik ... Morgan D Barense
    Anterior temporal lobe structures differentiated learned from non-learned crossmodal objects, evidence of integrated crossmodal object representations.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    MEMO1 binds iron and modulates iron homeostasis in cancer cells

    Natalia Dolgova, Eva-Maria E Uhlemann ... Oleg Y Dmitriev
    Cancer metastasis modulator MEMO1 binds iron and is involved in regulating iron homeostasis in cancer cells.
    1. Computational and Systems Biology

    Improved clinical data imputation via classical and quantum determinantal point processes

    Skander Kazdaghli, Iordanis Kerenidis ... Philip Teare
    A new data imputation method that can be implemented quantumly allows for better and more reliable classifications.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA

    Pascal Forcella, Niklas Ifflander ... Verdon Taylor
    1. Neuroscience

    Action sequence learning, habits, and automaticity in obsessive-compulsive disorder

    Paula Banca, Maria Herrojo Ruiz ... Trevor W Robbins
    Habit-based theories of obsessive-compulsive disorder are further elucidated by employing mobile phone motor sequence training, for which patients exhibited equivalent automatization, but enhanced value for the trained sequence, potentially ameliorating symptoms.
    1. Cell Biology

    Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile

    Yoko Nakai-Futatsugi, Jianshi Jin ... Masayo Takahashi
    Pigmentation that confers protective function of RPE is not underlaid by a specific gene expression profile, reviled by microscopic imaging together with single-cell RNA sequencing.
    1. Immunology and Inflammation

    Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt

    Phillip A Erice, Xinyan Huang ... Antony Rodriguez
    Mirlet7 functions as a molecular brake of CD8+IL17a+ T cells (Tc17) inflammation and chronic obstructive pulmonary disease via direct regulation RAR-related orphan receptor gamma t (RORγt).
    1. Computational and Systems Biology

    Heritable epigenetic changes are constrained by the dynamics of regulatory architectures

    Antony M Jose
    A foundation for analyzing epigenetic changes within the context of regulatory architectures that enable heredity.
    1. Immunology and Inflammation

    Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies

    Xiuyuan Lu, Hiroki Hayashi ... Sho Yamasaki
    Clonotypic tracing of SARS-CoV-2–responsive T cells reveals vaccination-induced dominant Tfh clonotypes, not pre-existing T cells, associated with sustained humoral response, and can serve as an index of antigen-specific antibody longevity.
    1. Chromosomes and Gene Expression

    The role of RNA in the maintenance of chromatin domains as revealed by antibody mediated proximity labelling coupled to mass spectrometry

    Rupam Choudhury, Anuroop Venkateswaran Venkatasubramani ... Axel Imhof
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