Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Sara M Frangos, Henver S Brunetta ... Graham P Holloway
Multi-omic and bioenergetic profiling in a HER2-driven mouse model of mammary cancer reveals that reduced mitochondrial content does not limit tumor respiratory capacity, which is instead dramatically elevated compared to benign mammary tissue.
Alicja Monaghan, Richard AI Bethlehem ... Duncan E Astle
Contrary to prior work, principal axes of structural and functional connectivity are established early in life, remaining stable and undergoing refinement throughout development.
Soenke Cordeiro, Robert Patejdl ... Marianne A Musinszki
Identification of mangostins as potent BK channel activators links natural xanthones to vascular smooth muscle relaxation, providing a mechanistic basis for their reported antihypertensive effects.
Theoretical and computational analyses demonstrate that cell intercalation within epithelial cell layers is analogous to the unbinding of topological defects in hexatic liquid crystals, offering a framework for calculating cellular forces and velocities during collective migration.
Mark van der Kroeg, Sakshi Bansal ... Femke MS de Vrij
Human stem cell-derived adherent cortical organoids in 384-well plates provide a reproducible, long-term cortical organoid platform with neurons, glia, and robust network activity, enabling scalable disease modeling and therapeutic screening.
A conserved neuropeptidergic circuit directly links internal glucose levels to sweet taste sensitivity, providing a central mechanism for coupling metabolic state to feeding behavior.
David Papadopoli, Ranveer Palia ... Ivan Topisirovic
Downregulation of the electron transfer flavoprotein dehydrogenase drives pro-tumorigenic metabolic programs via stimulating the mechanistic Target of Rapamycin Complex 1 signaling across a broad spectrum of cancers.
Allocating space, materials and energy to an eye's optics and photoreceptor array is a major factor in eye design that explains obvious differences between simple eyes and compound eyes.
Friederike Steenken, Rainer Beutelmann ... Georg M Klump
In aging gerbils, compromised temporal fine structure perception is explained by a more prominent representation in auditory nerve fibers of temporal fluctuations of the signal envelope, rather than by synaptopathy.
