Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Ecology
    2. Microbiology and Infectious Disease

    Tracking West Nile virus dynamics using viral loads from trapped mosquitoes

    Punya Alahakoon, Ian Marchinton ... James A Hay
    Mosquito-pool Ct values reflect biologically meaningful variation in viral load, while integrating viral kinetics improves prevalence estimates and helps distinguish potentially infectious from non-infectious mosquitoes.
    1. Developmental Biology
    2. Neuroscience

    foxQ2 marks fast-acting interneurons including dopaminergic neurons of mushroom bodies and central complex in the beetle Tribolium castaneum

    Ying Pang, Bastian Klußmann-Fricke ... Gregor Bucher
    In insects, foxQ2 is part of the genetic code that specifies neurons contributing to the higher-order brain centers, including dopaminergic and other fast-acting neurons.
    1. Developmental Biology

    Light-entrained chromatin priming poises rapid metamorphosis in a marine sponge

    Huifang Yuan, Oceane Blard ... Sandie M Degnan
    Planetary and habitat-specific environmental cues combine to induce rapid and extensive changes in chromatin state and gene expression necessary for larval settlement and metamorphosis in the marine sponge Amphimedon queenslandica.
    1. Cell Biology

    A GCN1-independent activator of the kinase GCN2

    JiaYi Zhu, Giulia Emanuelli ... Stefan J Marciniak
    GCN2 can be pharmacologically activated independently of GCN1, revealing flexibility in the mechanisms governing kinase activation.
    1. Developmental Biology
    2. Genetics and Genomics

    Integration of ATAC- and RNA-sequencing identifies chromatin and transcriptomic signatures in classical and non-classical zebrafish osteoblasts and indicates mechanisms of entpd5a regulation

    Kleio Petratou, Martin Stehling ... Stefan Schulte-Merker
    Computational analyses of large datasets and molecular dissection reveal the promoter organisation of the osteoblast marker entpd5a and suggest novel regulators of osteogenesis.
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    1. Ecology
    2. Plant Biology

    Genetic canalization of nutrient resorption in the widespread grass Phragmites australis under salt stress

    Lele Liu, Wenyi Sheng ... Weihua Guo
    Salinity does not alter nutrient resorption efficiency, which is instead shaped by phylogeographic history and latitude.
    1. Cell Biology

    Small brown planthopper infestation enhances it reproduction and insecticide tolerance by manipulating glucose distribution and levels in rice

    Hainan Zhang, Qi Zhang ... Jianjun Wang
    Small brown planthopper infestation drives rice glucose redistribution to boost its own reproduction and insecticide tolerance.
    1. Neuroscience

    The transcription factor BCL11A restores differentiation potential to aged oligodendrocyte progenitor cells

    Tanay Ghosh, Roey Baror ... Robin JM Franklin
    gSWITCH identifies dynamic lineage switch genes and reveals BCL11A as an evolutionarily conserved regulator whose restoration rescues age-impaired oligodendrocyte progenitor cell differentiation.
    1. Biochemistry and Chemical Biology

    SARS-CoV-2 main protease inhibition through dimerization promotion by peptidomimetic inhibitors and disruption by ebselen

    Chengxi Liu, Qinyu Jia ... Zhong-Ping Yao
    Distinct effects of peptidomimetic inhibitors and ebselen on SARS-CoV-2 main protease dimerization reveal new strategies for antiviral drug design.
    1. Structural Biology and Molecular Biophysics

    Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

    Kexin Zhang, Timothy Grant, Nikolaus Grigorieff
    High-resolution structural information can be recovered from proteins well below the conventional cryo-electron microscopy size range, substantially extending the range of complexes accessible to structural analysis.
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