Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Rochelle M Shih, Yasuhiro Arimura ... Hironori Funabiki
DNA methylation suppresses H2A.Z deposition by inhibiting recruitment of the chaperone SRCAP, while the structural study suggests that methylated DNA can make the H2A.Z nucleosome slightly more accessible.
Although auditory encoding of music is robust early in infancy, the transformation of this input into movement patterns develops substantially over the first postnatal year, without reaching full maturity.
Michael C Frank, Virginia A Marchman ... Martin Zettersten
Analysis of data across many different studies shows that children's word recognition improves continuously from infancy through age 5 years, and shows strong coupling with early vocabulary.
Nickase and nuclease Prime Editors offer complementary routes for precise zebrafish genome editing, balancing accuracy for substitutions with efficiency for short insertions.
Elin Larsson, Aleksei Kabedev ... Richard Lundmark
Membrane insertion of Dyngo-4a results in a dynamin-independent inhibition of caveola dynamics, revealing that outer leaflet lipid packing in the plasma membrane contributes to the confinement of caveolae.
Gaseous CO2 acts as a neuron to glia messenger in peripheral myelin to trigger opening of Schwann Cell Cx32 hemichannels in response to axonal action potential propagation.
Genetic experiments integrated with ChIP-sequencing and CRISPR interference reveal that overexpression of Foxc1 transcriptionally activates the expression of Arhgap36 and dysregulates multiple facets of Hedgehog pathway activity.
Sohrab Salimian, Harrison Grier, Matthew Tyler Kaufman
Single neurons in mouse sensorimotor cortex are organized by their activity features into distinct subpopulations with area-spanning footprints whose boundaries align closely with anatomical and somatotopic borders.
