Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Computational and Systems Biology

    A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging

    Sergiy Libert, Alex Chekholko, Cynthia Kenyon
    A model was developed to predict human biological age from physiological traits, enabling the prediction of future health and mortality and the identification of genetic loci that influence aging.
    1. Neuroscience

    Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI

    Joonas A Autio, Ikko Kimura ... Takuya Hayashi
    Ferumoxytol-enhanced MRI enables high-resolution, laminar mapping of cerebral blood volume in the primate brain, validating core neurovascular features and advancing noninvasive tools for neurometabolic imaging.
    1. Cell Biology
    2. Genetics and Genomics

    Kinesin-2 autoinhibition requires elbow phosphorylation

    Guanghan Chen, Zhengyang Guo ... Guangshuo Ou
    Phosphorylation of the kinesin-2 motor protein’s elbow region by NEKL-3 kinase maintains autoinhibition, enabling its transport to cilia for sensory function.
    1. Neuroscience

    Embedding stochastic dynamics of the environment in spontaneous activity by prediction-based plasticity

    Toshitake Asabuki, Claudia Clopath
    A computational model shows how synaptic plasticity shapes spontaneous activity to encode the transition statistics of sensory experience.
    1. Microbiology and Infectious Disease

    Caffeic acid phenethyl ester protects Clostridioides difficile infection by toxin inhibition and microbiota modulation

    Yan Guo, Yong Zhang ... Jiazhang Qiu
    Caffeic acid phenethyl ester treats Clostridioides difficile infection by neutralizing Clostridioides difficile toxin B and altering the gut microbiota and metabolites.
    1. Developmental Biology
    2. Neuroscience

    A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila ventral nerve cord

    Jelly HM Soffers, Erin Beck ... Haluk Lacin
    A temporally stable and cell-type-specific genetic driver library provides the means to access and manipulate neuronal lineages in the fly nervous system during development and adulthood.
    1. Developmental Biology
    2. Neuroscience

    Activity-dependent synapse elimination requires caspase-3 activation

    Zhou Yu, Andrian Gutu ... Erin K O'Shea
    Caspase-3 activation links synapse weakening to synapse elimination.
    1. Neuroscience

    Human brain ancestral barcodes

    Darryl Shibata
    A dynamic DNA methylation 'barcode' on the X chromosome can distinguish thousands of individual adult male neurons and may record aspects of their development.
    1. Cell Biology
    2. Genetics and Genomics

    Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy

    San Pin Steve Wu, Elvis Quiroz ... Francesco J DeMayo
    Genome-wide epigenetic profiling reveals chromatin regions in the human myometrium involved in functional regulation and hormonal control during pregnancy.