Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Yoshinori Kohwi, Xianrong Wong ... Terumi Kohwi-Shigematsu
Modified ChIP-seq and 4C-seq approaches, using urea-purified crosslinked chromatin, uncovered a two-tiered chromatin organization mediated by SATB1 that is linked to gene expression.
Shivraj M Yabaji, Vadim Zhernovkov ... Igor Kramnik
Myc dysregulation in activated macrophages impairs antioxidant defenses, locking them in a vicious cycle that amplifies type I interferon signaling, driving hyperinflammation and immunosuppression.
Age-related differences in cortical aperiodic signals can be driven by cardiac influences, emphasizing the need to control for cardiac contributions in studies interpreting cortically measured aperiodic dynamics.
Endophilin A1 at postsynaptic sites promotes inhibitory postsynaptic organization through interaction with gephyrin to maintain E/I balance, which is essential for the suppression of epilepsy susceptibility.
Hey-Kyeong Jeong, Estibaliz Gonzalez-Fernandez ... Gareth M Thomas
Loss of ZDHHC9, a protein acyltransferase that is highly expressed in oligodendrocytes, does not grossly impact myelination but markedly alters oligodendrocyte morphology and myelination at the micro/nano-scale.
Patchy striatonigral neurons regulate implicit locomotor speed selection based on environmental valence, revealing a subtype-specific mechanism by which striatal circuits shape adaptive motor control and value-dependent behavioral responses.
Across multiple scales, temporal context shapes visual perception through an attention-dependent process facilitating rapid motor responses and an attention-independent process suppressing neural encoding of expected events.
