Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Rule-based modulation of a sensorimotor transformation across cortical areas

    Yi-Ting Chang, Eric A Finkel ... Daniel H O'Connor
    Preparatory states within the motor cortex play a critical role in selecting an appropriate action in response to sensory input, dependent on the context.
    1. Developmental Biology

    Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling in Drosophila

    Andrew Liu, Jessica O’Connell ... Richard W Carthew
    Two atypical cadherins regulate organ growth by tuning the coupling of cell cycle duration to organ size.
    1. Structural Biology and Molecular Biophysics

    A parameterized two-domain thermodynamic model explains diverse mutational effects on protein allostery

    Zhuang Liu, Thomas G Gillis ... Qiang Cui
    A combined theoretical and experimental study revealed the mechanistic and structural basis of mutational effects on allostery and provided insights into the intrinsic connection of intra- and inter-domain properties.
    1. Cell Biology
    2. Physics of Living Systems

    Partitioning to ordered membrane domains regulates the kinetics of secretory traffic

    Ivan Castello-Serrano, Frederick A Heberle ... Ilya Levental
    Direct measurements of trafficking kinetics between organelles of the secretory pathway suggest that lipid-driven membrane domains laterally sort proteins during membrane traffic.
    1. Immunology and Inflammation

    G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

    Yi-Hong Li, Yi-Sen Yang ... Liquan Huang
    Conditional abolishment of a G protein subunit in a subset of ectopic tuft cells engenders severer injury, slower recovery, and increased fatality following the infection of the influenza viruses.
    1. Developmental Biology

    Loss of ninein interferes with osteoclast formation and causes premature ossification

    Thierry Gilbert, Camille Gorlt ... Andreas Merdes
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA

    Pascal Forcella, Niklas Ifflander ... Verdon Taylor
    Extensive analysis shows that the RNA-binding protein SAFB binds to Drosha in hippocampal stem cells and controls oligodendrocyte fate commitment through post-transcriptional regulation of NFIB expression.
    1. Neuroscience

    Ingestible pills reveal gastric correlates of emotions

    Giuseppina Porciello, Alessandro Monti ... Salvatore Maria Aglioti
    Direct measures of inner gastrointestinal signals via ingestible capsules highlight the role of stomach pH in shaping human feelings of disgust, fear and happiness.
    1. Neuroscience

    Tracking the neurodevelopmental trajectory of beta band oscillations with optically pumped magnetometer-based magnetoencephalography

    Lukas Rier, Natalie Rhodes ... Matthew J Brookes
    The first neurodevelopmental study using a novel, wearable brain imaging system based on optically pumped magnetometers, shows age-related changes in neural oscillatory task responses and cortical functional connectivity.