Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Many well-studied maternal developmental pathways that are required for embryonic development in Drosophila are regulated by the transcription factor OVO in the Drosophila female germline.
Audrey T Medeiros, Scott J Gratz ... Kate M O'Connor-Giles
In vivo analysis of endogenously tagged Ca2+ channel subunits reveals unexpected differences in subunit composition and synapse-specific relationships between channel abundance and synaptic strength.
Behavioral studies reveal that bumblebees distinguish between continuous and interrupted strings by using a combination of image matching and associative learning.
Ernie Yulyaningsih, Jung H Suh ... Pascal E Sanchez
DNL343, a brain-penetrant integrated stress response inhibitor, reduces neurodegeneration in mouse models and identifies biomarker candidates for assessing treatment responses in clinical settings.
Stefan Passlick, Ghanim Ullah, Christian Henneberger
Synaptic glutamate release is potentiated by short metabolic failure whereas longer durations of energy depletion lead to a postsynaptic failure of synaptic transmission.
Comparative structural analysis and biochemical characterization unraveled the mechanisms behind enzymatic substrate selectivity, leading to an amplified theanine yield through active mutant protein screening, thus refining strategies for theanine production.
Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for baseline breathing and hypercapnic, hypoxic chemosensory reflexes, which challenges the current understanding of central noradrenergic neurons in breathing control.
OsNF-YB7, an ortholog of Arabidopsis LEC1, is a negative regulator of Chl biosynthesis in rice embryos by interacting with OsGLK1 to inhibit the transactivity of OsGLK1.
