Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Medicine

    Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

    Megan M Sperry, Berenice Charrez ... Donald E Ingber
    Repurposing of a drug designed for pain relief can quickly and reversibly slow biochemical and metabolic activities in cells and organs and could facilitate organ transplantation and prevent tissue injury.
    1. Neuroscience

    When and why does motor preparation arise in recurrent neural network models of motor control?

    Marine Schimel, Ta-Chu Kao, Guillaume Hennequin
    A computational model shows that preparation arises as an optimal control strategy in input-driven recurrent neural networks performing a delayed-reaching task.
    1. Neuroscience

    Distractor effects in decision making are related to the individual’s style of integrating choice attributes

    Jing Jun Wong, Alessandro Bongioanni ... Bolton KH Chau
    Computational modelling reveals variations in people’s preferences towards integrating choice attributes using an additive or multiplicative approach, which affected whether the presence of valuable distractors facilitate or impair decision making.
    1. Neuroscience

    The subthalamic nucleus contributes causally to perceptual decision-making in monkeys

    Kathryn Branam, Joshua I Gold, Long Ding
    The subthalamic nucleus contains distinct subpopulations that can support multifaceted roles for making decisions based on uncertain evidence.
    1. Cancer Biology
    2. Genetics and Genomics

    Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases

    Joakim W Karlsson, Vasu R Sah ... Jonas A Nilsson
    Single-cell sequencing and functional analysis identify T cells that can be useful for marker selection and cell therapy in uveal melanoma, a disease largely unresponsive to conventional immune checkpoint therapies.
    1. Cancer Biology
    2. Neuroscience

    Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer

    Jeffrey Barr, Austin Walz ... Paola D Vermeer
    Nerve tracing and behavioral studies in tumor-bearing mice together with transcriptional and functional analysis reveal cancer-induced central and peripheral neuronal alterations that influence behavior.
    1. Neuroscience

    Sensitivity to vocal emotions emerges in newborns at 37 weeks gestational age

    Xinlin Hou, Peng Zhang ... Dandan Zhang
    Analysis of neonatal response reveals that at 37 weeks gestational age, infants exhibit a marked developmental shift in their ability to perceive emotional vocal prosody, highlighting a critical period for social emotional development with potential implications for early neurodevelopmental assessments.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation

    Matthew C Pahl, Prabhat Sharma ... Andrew D Wells
    The three-dimensional architecture of the genome in distinct cell types predicts genes and regulatory elements involved in cell function and disease.
    1. Cancer Biology

    PITAR, a DNA damage-inducible cancer/testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

    Samarjit Jana, Mainak Mondal ... Kumaravel Somasundaram
    PITAR interaction with TRIM28 mRNA, which encodes a p53 targeting E3 ubiquitin ligase, keeps p53 levels low for cancer cells to divide and attenuates the DNA damage response by p53.