2,142 results found
    1. Neuroscience

    Rapid, automated, and experimenter-free touchscreen testing reveals reciprocal interactions between cognitive flexibility and activity-based anorexia in female rats

    Kaixin Huang, Laura K Milton ... Claire J Foldi
    An automated touchscreen cognitive testing system for rats reduces the length of training required to learn tasks, making it possible to assess cognitive profiles in adolescent animals to more appropriately capture cognitive deficits in adolescent pathologies, such as anorexia nervosa.
    1. Medicine
    2. Physics of Living Systems

    High spatial resolution analysis using automated indentation mapping differentiates biomechanical properties of normal vs. degenerated articular cartilage in mice

    Anand O Masson, Bryce Besler ... Roman J Krawetz
    The method presented here allows researchers to retrieve accurate and reproducible biomechanical properties of mouse cartilage.
    1. Neuroscience

    Eco-HAB as a fully automated and ecologically relevant assessment of social impairments in mouse models of autism

    Alicja Puścian, Szymon Łęski ... Ewelina Knapska
    An innovative, fully computerized approach for measuring spontaneous social behavior in mice closely follows murine ethology, eliminates crucial sources of data irreproducibility and enables fast, inexpensive assessment of sociability in group-housed subjects.
    1. Neuroscience

    MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment

    Flavio H Beraldo, Daniel Palmer ... Marco AM Prado
    Comprehensive dataset of high-level cognitive assessment in mouse models of neurodegeneration, accompanied by an open-access database/repository to change the paradigm of how cognitive studies in animal models can be shared/re-used.
    1. Stem Cells and Regenerative Medicine

    A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

    Henrik Renner, Martha Grabos ... Jan M Bruder
    Automated liquid handling, whole mount staining, and clearing allow unbiased 3D quantitation of cell markers in human neural organoids with diameters of up to 1 mm at the single-cell level.
    1. Structural Biology and Molecular Biophysics

    Automated systematic evaluation of cryo-EM specimens with SmartScope

    Jonathan Bouvette, Qinwen Huang ... Mario J Borgnia
    SmartScope is the first software package designed to streamline, standardize, and fully automate screening of specimens in cryo-electron microscopy, providing real-time remote control of the microscope and access to data through a standard web interface.
    1. Neuroscience

    Assessing the effects of stress on feeding behaviors in laboratory mice

    Marie Francois, Isabella Canal Delgado ... Lori Zeltser
    Systematic testing of experimental variables in a common neurobehavioral paradigm revealed that conditions that more closely match human physiology reliably elicit stress eating in mice.
    1. Neuroscience

    Fully autonomous mouse behavioral and optogenetic experiments in home-cage

    Yaoyao Hao, Alyse Marian Thomas, Nuo Li
    A fully automated workflow for high-throughput mouse behavioral and optogenetic experiments in homecage reveals involvement of brain regions in tactile decision-making.
    1. Neuroscience

    The neural basis for a persistent internal state in Drosophila females

    David Deutsch, Diego Pacheco ... Mala Murthy
    A set of sexually dimorphic neurons in female flies is part of a recurrent neural network and drives minutes-long persistent neural activity and persistent social behaviors.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Time-resolved mapping of genetic interactions to model rewiring of signaling pathways

    Florian Heigwer, Christian Scheeder ... Michael Boutros
    Genetic interaction analysis by combinatorial genetic perturbation and high-throughput imaging maps time- and context-dependent crosstalk between signaling pathways.

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