285 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Task-dependent optimal representations for cerebellar learning

    Marjorie Xie, Samuel P Muscinelli ... Ashok Litwin-Kumar
    Classical theoretical approaches to studying the cerebellar cortex are generalized to a broader set of learning tasks, revealing that the optimal value for the sparsity of granule cell activity is task-dependent.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop

    Paulina Fuentes, Fei Zhou ... Ralph Bock
    A combination of chloroplast transformation with nuclear transformation and large-scale metabolic screening of supertransformed plant lines has enabled an entire biochemical pathway to be transferred from a medicinal plant to a high-biomass crop.
    1. Neuroscience

    Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila

    Carlotta Martelli, André Fiala
    Slow presynaptic depression in olfactory receptor neurons rescales combinatorial odor representations in postsynaptic neurons and mediates the encoding of stimulus mean and variance.
    1. Neuroscience

    Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality

    Brian Kim, Seth Haney ... Mark A Stopfer
    The odor-elicited responses of olfactory receptor neurons consist of a discrete set of four spike pattern motifs, each with distinct adaptation properties, together amplifying distinctions between similar and temporally complex chemical inputs such as odor plumes.
    1. Cancer Biology

    Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression

    Viviana Anelli, Jacques A Villefranc ... Yariv Houvras
    Transformation mediated by oncogenic BRAF requires transcriptional activation of TWIST at the earliest stage of neoplastic transformation.
    1. Computational and Systems Biology
    2. Neuroscience

    Place-cell capacity and volatility with grid-like inputs

    Man Yi Yim, Lorenzo A Sadun ... Thibaud Taillefumier
    A very large number of place-field maps can be robustly learned by association of external cues with the grid-driven response, however plasticity in the grid-cell inputs renders the place-cell responses volatile.
    1. Computational and Systems Biology
    2. Neuroscience

    Front-end Weber-Fechner gain control enhances the fidelity of combinatorial odor coding

    Nirag Kadakia, Thierry Emonet
    In multi-channel sensory systems, gain adaptation can help maintain not only coding capacity across changes in signal intensity, but also combinatorial representations of odor identity.
    1. Developmental Biology

    Genetic dissection of the Transcription Factor code controlling serial specification of muscle identities in Drosophila

    Laurence Dubois, Jean-Louis Frendo ... Alain Vincent
    Lineage-specific regulatory loops involving evolutionarily conserved myogenic Transcription Factors control muscle identity specification in Drosophila.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Time-resolved mapping of genetic interactions to model rewiring of signaling pathways

    Florian Heigwer, Christian Scheeder ... Michael Boutros
    Genetic interaction analysis by combinatorial genetic perturbation and high-throughput imaging maps time- and context-dependent crosstalk between signaling pathways.
    1. Developmental Biology
    2. Neuroscience

    Tuning of delta-protocadherin adhesion through combinatorial diversity

    Adam J Bisogni, Shila Ghazanfar ... David M Lin
    Combinatorial expression patterns of δ-Pcdhs are defined within single neurons, and in vitro assays are employed to establish guiding principles used by this gene family to mediate cell adhesion.

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