The accumulation of carbon black nanoparticles in smokers' lungs causes sterile inflammation, double-strand DNA breaks and emphysema.

A functional genetic variant, rs1690789, affects susceptibility to emphysema by altering TGFB2 expression in human lung fibroblasts.

Mirlet7 functions as a molecular brake of CD8⁺IL17a⁺ T cells (Tc17) inflammation and chronic obstructive pulmonary disease via direct regulation RAR-related orphan receptor gamma t (RORγt).

Mitochondrial activity and distribution control alveolar formation by conferring distinct cellular properties.

Generation of a human lung single nucleus ATAC-seq and single nucleus RNA-seq datasets reveals candidate cis-regulatory elements that advance knowledge on gene expression control in normal and diseased lungs.

Phase contrast X-ray tomography based on a combination of parallel and cone beam geometry extends conventional histology by a third dimension and enables full quantication of tissue remodeling in COVID-19.

Chronic, daily inhalation of e-cigarette aerosols alters the inflammatory state of multiple organ systems, including the brain, heart, lung and colon.

Finding that circulating Z alpha-1 antitrypsin polymers, a feature of ZZ AAT deficiency, lower the expression of CX3CR1 on peripheral blood mononuclear cells encourages more detailed analyses on different circulating misfolded proteins and their role on immune cell surveillance/function.

After acute lung injury, the transcription factor Atf3 is essential for regeneration of the capillary endothelium, which is critical for restoring the structure of the lung alveolus.