4,408 results found
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Kinetic sculpting of the seven stripes of the Drosophila even-skipped gene

    Augusto Berrocal, Nicholas C Lammers ... Michael B Eisen
    Live quantitative monitoring of transcriptional bursting reveals that enhancers responding to different regulators use the same kinetic strategy to produce a complex composite pattern of developmental expression.
    1. Developmental Biology

    Cellular resolution models for even skipped regulation in the entire Drosophila embryo

    Garth R Ilsley, Jasmin Fisher ... Nicholas M Luscombe
    A statistical model is able to predict patterns of gene expression output in Drosophila embryos using only the cellular concentrations of transcription factors as input.
    1. Neuroscience

    Cortex commands the performance of skilled movement

    Jian-Zhong Guo, Austin R Graves ... Adam W Hantman
    Optogenetic inhibition demonstrates that the cortex is necessary and sufficient for the initiation and execution of a learned, skilled action.
    1. Developmental Biology

    Development: Computing away the magic?

    Michael Levine
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    1. Neuroscience

    One-shot generalization in humans revealed through a drawing task

    Henning Tiedemann, Yaniv Morgenstern ... Roland W Fleming
    Humans are able to generate a complete category of varied objects from just one exemplar shape, identifying and utilizing its most distinctive parts to create a coherent group, even for other observers.
    1. Developmental Biology
    2. Evolutionary Biology

    Dual mode of embryonic development is highlighted by expression and function of Nasonia pair-rule genes

    Miriam I Rosenberg, Ava E Brent ... Claude Desplan
    Pair-rule genes in the wasp Nasonia function as in Drosophila in patterning anterior segments, and similar to ancestral insects in patterning posterior segments, illustrating a mixed-mode transition state between short and long germ embryogenesis.
    1. Structural Biology and Molecular Biophysics

    A cryogenic, coincident fluorescence, electron, and ion beam microscope

    Daan B Boltje, Jacob P Hoogenboom ... Sander den Hoedt
    Integrating a cryogenic light microscope with a focused ion beam/scanning electron microscope, allows directly targeting of fluorescent structure when preparing a frozen-hydrated lamella, without the need for repositioning or fiducial markers.
    1. Neuroscience

    Comprehension of computer code relies primarily on domain-general executive brain regions

    Anna A Ivanova, Shashank Srikant ... Evelina Fedorenko
    The domain-general executive brain regions support the use of a novel cognitive tool even when it is structurally similar to natural language.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology

    Xiao Tao, Roderick MacKinnon
    The structure of KvAP addresses a mechanism of voltage-dependent gating that has been debated for 16 years.

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