1,318 results found
    1. Stem Cells and Regenerative Medicine

    Nuclear receptor NR4A is required for patterning at the ends of the planarian anterior-posterior axis

    Dayan J Li, Conor L McMann, Peter W Reddien
    NR4A is a broadly conserved transcription factor that is required for concordance of patterning information and anatomy at both ends of the planarian anterior-posterior axis.
    1. Developmental Biology

    Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord

    Héctor Sánchez-Iranzo, Aliaksandr Halavatyi, Alba Diz-Muñoz
    Interaction strength in Notch signaling determines lateral inhibition patterning and drives fate in the unidimensional cell arrangement of the zebrafish notochord.
    1. Developmental Biology
    2. Neuroscience

    A Notch-dependent transcriptional mechanism controls expression of temporal patterning factors in Drosophila medulla

    Alokananda Ray, Xin Li
    Cell-cycle-dependent Notch signaling cooperates with temporal transcription factors to promote the progression of the temporal transcription factor cascade in Drosophila medulla neuroblasts.
    1. Developmental Biology
    2. Physics of Living Systems

    Self-organized patterning of cell morphology via mechanosensitive feedback

    Natalie A Dye, Marko Popović ... Frank Jülicher
    Radial patterns of cell morphology in the Drosophila larval wing emerge through mechanosensitive dynamics of cell polarity.
    1. Developmental Biology
    2. Evolutionary Biology

    Hedgehog signaling is required for endomesodermal patterning and germ cell development in the sea anemone Nematostella vectensis

    Cheng-Yi Chen, Sean A McKinney ... Matthew C Gibson
    The dependence of Nematostella germ cell specification on zygotic Hedgehog pathway activity supports the hypothesis that the eumetazoan common ancestor segregated its germline by inductive signals rather than maternal determinants.
    1. Developmental Biology

    Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse molars

    Junjun Jing, Jifan Feng ... Yang Chai
    Ezh2 and Arid1a oppose each other to control expression of Cdkn2a to coordinate tooth furcation development and ultimately determine the number of roots in mouse molars.
    1. Developmental Biology

    The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland

    Aleksander D Szymaniak, Rongjuan Mi ... Xaralabos Varelas
    The transcriptional regulator YAP directs the specification and differentiation of stem cells that give rise to salivary gland ductal epithelium.
    1. Computational and Systems Biology
    2. Developmental Biology

    Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning

    Autumn P Pomreinke, Gary H Soh ... Patrick Müller
    Patterning of the dorsal-ventral axis in zebrafish is mediated by a graded source-sink mechanism in which diffusing BMP, produced from a ventrally biased source, is inhibited by dorsally-produced chordin.
    1. Cell Biology
    2. Developmental Biology

    The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth

    Shu Yang, Xuefeng Wu ... Xiaoyan Zheng
    The NDNF-like factor Nord is a Hedgehog-induced and extracellular-localized dosage-dependent BMP modulator that regulates Drosophila wing patterning and growth.
    1. Developmental Biology

    Nodal patterning without Lefty inhibitory feedback is functional but fragile

    Katherine W Rogers, Nathan D Lord ... Alexander F Schier
    Lefty-mediated feedback inhibition of Nodal signaling mitigates signaling perturbations, but is dispensable for development.

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