Assays using recombinant HIF prolyl hydroxylases did not support hydroxylation of more than 20 reported non-HIF substrates under conditions where robust HIF hydroxylation was observed.

A novel developmental mechanism generates a previously undescribed pair of sex-specific proprioceptive neurons required for male-specific behaviour.

Visualization of the real-time conformational transitions of the human voltage-gated proton channel hHv1 provided novel insights into how voltage and pH gradients modify the dynamic behaviors of channel structures to control proton flow across membrane.

The X-ray structure of the PaNhaP provides a unique view of substrate-ion binding and release in electroneutral sodium/proton antiporters.

High-resolution maps and models of the bacterial ribosome provide new chemical insights into protein synthesis, and should enable the development of robust tools for cryo-EM structure modeling and refinement.

Visual, parietal, and frontal motor cortices play distinct and necessary roles in mapping sensory features to future motor action.

A method to assess the training of scientists, based on a set of 10 core competencies, is proposed.

A systems-level analysis of the biomedical workforce in the US shows that current strategies to enhance faculty diversity are unlikely to have a significant impact, and that there is a need to increase the number of PhDs from underrepresented minority backgrounds who move on to postdoctoral positions.

The sour receptor, OTOP1, and related proton channel OTOP3 are steeply activated by extracellular protons while OTOP2 is active over a broad pH range and differences in gating are partly attributed to extracellular domains.

The BPTF PHD finger is inhibited from binding the methylated H3 tails in the context of the nucleosome due to their robust interaction with the nucleosomal DNA, which can be modulated by additional histone PTMs.