Lisa Baumgartner, Dominik Handler ... Julius Brennecke
Kipferl, a ZAD zinc finger protein from Drosophila, determines the chromatin binding specificity of the heterochromatin protein variant Rhino, defining piRNA clusters and preventing Rhino sequestration by selfish Satellite repeats.
Kevin I Manage, Alicia K Rogers ... Carolyn Marie Phillips
SIMR-1 acts downstream of the piRNA pathway to promote siRNA amplification by the Mutator complex and localizes to perinuclear foci distinct from Mutator foci, P granules and Z granules.
Selective degradation of mature miRNAs shapes temporal miRNA expression patterns and is important for proper regulation of target genes to support normal development of Drosophila embryos.
Ana Filipa Domingues, Rashmi Kulkarni ... Cristina Pina
Histone acetyl-transferase Kat2a preserves leukemia stem cells through frequent transcriptional firing of metabolic and regulatory gene promoters and maintenance of a largely invariant self-renewal program.
To protect the germ line genome, chickens acquire new small RNA-based immune defense in response to recently endogenized retroviruses by turning a truncated provirus into a weapon.
Martin H Fabry, Federica A Falconio ... Gregory J Hannon
Maternally deposited Piwi-piRNA complexes co-transcriptionally repress transposable elements that transiently become active in somatic cells of the developing Drosophila embryo.
Martin H Fabry, Filippo Ciabrelli ... Benjamin Czech
A member of the Drosophila Nuclear Export Factor (Nxf) family, Nxf2, forms part of the piRNA-dependent co-transcriptional silencing complex and is essential for transposon repression in fly ovaries.
Karine Casier, Valérie Delmarre ... Antoine Boivin
Activation of a piRNA cluster is achieved by high temperature and without maternal inheritance of homologous piRNAs highlighting how variations of species natural habitat can become heritable and shape epigenome.
Charline Sophie Pinna, Maëlle Vilbert ... Marianne Elias
Wing transparency in mimetic butterflies and moths is achieved by an unexpected diversity of structural features, and both structures and light transmission properties of wings are under selection for convergence.