Thousands of "noncoding" RNAs, 5' "untranslated" regions, and pseudogenes in humans are actually translated, and some of these are likely to express functional proteins.
The partial success of a study to reproduce experiments that linked pseudogenes and cancer proves that understanding RNA networks is more complicated than expected.
John Kerwin, Israr Khan, Reproducibility Project: Cancer Biology
Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
Over 7,000 novel translated sequences have been identified from human cells, including several hundred in annotated noncoding RNA, pseudogenes and de novo assembled transcripts.
Pseudogenization of rcsD alters canonical Rcs phosphorelay signalling and marks a significant adaptive evolutionary step in the emergence of ubiquitous extant branches of Yersinia pestis that can maintain stable plague outbreaks.