A high-resolution picture of genetic complexity and network perturbations underlying cardiac inter-atrial septal dysmorphology associated with patent foramen ovale, a common human congenital anomaly, using quantitative trait locus mapping, genome sequencing, and transcriptomics in a mouse model.

The expression of small RNAs (or sRNAs) is regulated not only by mRNA expression, but also by their own regulatory elements and by sRNA biogenesis genes.

Whole genome DNA sequence analysis, genome wide gene expression and complex organismal phenotypes in Drosophila mutation accumulation lines provide a robust estimate of the spontaneous mutation rate and mutational effects.

It is always better to use mixed effects models over principal components association regression for genetic association studies of continuous traits, since the former models family structure and close relatives are always found in real human studies.

A long-term multi-organ co-culture system coupled with quantitative imaging to visualize blood cell cycle progression, analyze polarized blood cell mitosis, and track blood cell differentiation kinetics during Drosophila hematopoiesis in homeostatic condition and following infection.

eLife publishes advances in quantitative genetics, including the genetic basis of complex traits, the maintenance of genetic variation, and their roles in evolution.

Arabidopsis shows extensive genetic diversity in germination time distributions, which can be explained by the underlying ABA/GA network functioning as a noisy bistable switch.

A mutant allele encoding a deregulated subunit of an ion channel tetramer revealed a mechanistic connection between protein heteromerization and quantitative genetic behavior.

Copy number alteration heterogeneity exists in many shapes and forms in breast cancer genomes and single-cell genomics is a powerful tool to further our understanding of its nature and significance.

During Drosophila axis elongation, the orientational pattern of the cytoskeleton is in good approximation stationary, while the genes thought to instruct these patterns are transported with the tissue flow.