MLL1-mediated H3K4 methylation is directly enhanced by cis-tail H3 acetylation, as shown through both in vitro and in vivo experiments.

Biochemical analysis in Xenopus egg extracts reveals that the MutSα mismatch sensor retains the DNA-bound replication clamp to maintain a post-replicative temporal window permissive to strand-specific repair of mismatches.

Stimulation of specific neurons within the hypothalamus triggers a fear-like emotion state and behavioral response in mice, challenging the textbook view that the hypothalamus serves simply as a relay for emotion states encoded in the amygdala.

Sex-specific characteristics of the fruit fly courtship behavior are not specified by a single binary switch, but as a combination of traits that are modularly specified by separable genetic switches.

An implantable device based on organic electrochemical transistors is developed for quantitative mapping of neurotransmitter release across multiple brain regions, revealing a cross-talk between the mesolimbic and nigrostriatal dopaminergic pathways.

Modifying the recurrent connectivity of spiking networks provides sufficient flexibility to generate arbitrarily complex recurrent dynamics, suggesting that individual neurons in a recurrent network have the capability to support near universal dynamics.

aLENS implements new parallel methods to resolve cytoskeletal assembly dynamics with high stability, physical consistency, and scalability.

Single-molecule immunoprecipitation method reveals that the high catalytic rate and multi-tasking capability make a concerted contribution to the strong signaling potency of the HER2-HER3 heterodimers.

AIDPS derived by 76 machine-learning algorithm combinations in 13 independent multicenter cohorts exhibited superior capability than clinical traits and 86 published prognostic signatures and could serve as an ideal biomarker for stratified management and individualized treatment of pancreatic cancer.

A novel method and software provides researchers with the capability to rapidly, flexibly, and robustly perform Bayesian parameter estimation of theoretically meaningful models in cognitive neuroscience that were heretofore intractable.