Soon after fertilisation, a critical portion of the embryonic genome is switched on through the actions of maternally inherited Stella, in part through controlling the activation of transposable elements.

Background selection is shown to be the dominant mode of linked selection in humans, with marked effects on diversity levels throughout autosomes.

The auxin-sensitive Aux/IAA transcriptional repressors regulate approximately 35% of the annotated genes in Physcomitrella patens and exhibit complex interactions with both the activating and repressing ARF transcription factors.

The basal body of the type-III secretion system of Yersinia enterocolitica within bacterial membranes shows elasticity and is longer than related isolated systems.

A landmark-based cross-modality alignment method robust to variation in landmark sets is applied to annotate an EM time series of Caenorhabditis elegans embryonic development as a community resource.

Predators may amplify multiple-host parasite spreading in systems with multiple transmission routes.

The discovery of three distinct and independent trans-regulating genomic loci influencing heart mass using a well-characterized mouse reference population provides evidence in support of the hypothesis that genetic diversity in the mitochondrial proteome plays a critical role in heart pathophysiology.

An unbiased proteomics approach in human cells identifies ZC3H4 and shows that it is important for controlling the transcription of unstable RNA synthesized upstream of promoters and over enhancers.

A computational model for the formation of neural networks of grid cells in virtual bats suggests that the highly ordered networks presumed to support spatial navigation in two dimensions cannot be routinely established in three-dimensional space.

The cysteine pair oxidation state in nDsbD acts as a ‘switch’ controlling the presence or absence of frustration in the active-site and determining the dynamic behavior of the cap loop.