Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.
Gervasio Batista, Jennifer Leigh Johnson ... Jose L Pena
Behavioral pharmacology and molecular biology reveal a translational control mechanism underlying auditory imprinting and structural plasticity that can be pharmacologically manipulated to reopen the critical period.
Musashi-mediated post-transcriptional mechanisms regulate glucuronoxylan modification and secondary cell wall formation in the supportive fibre cells of stem in plants.
Measurements of transcript isoform specific translation across the human genome reveal that isoforms from the same gene can differ in protein production by two orders of magnitude.
Andon N Placzek, Gonzalo Viana Di Prisco ... Mauro Costa-Mattioli
Building on previous work (Huang et al., 2016), we show that translational control by p-eIF2α is a defense mechanism that prevents persistent cocaine-induced synaptic synaptic potentiation underlying compulsive drug seeking.
Arkady Khoutorsky, Robert P Bonin ... Nahum Sonenberg
The mTOR downstream effector eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) regulates mechanical nociception via translational control of synaptic transmission in the spinal cord.