Prabhat S Kunwar, Moriel Zelikowsky ... David J Anderson
Stimulation of specific neurons within the hypothalamus triggers a fear-like emotion state and behavioral response in mice, challenging the textbook view that the hypothalamus serves simply as a relay for emotion states encoded in the amygdala.
Alison H Affinati, Paul V Sabatini ... Alan C Rupp
This atlas and analysis of conserved ventromedial hypothalamic nucleus (VMH) neuron populations provides an unbiased starting point for the analysis of VMH circuitry and function.
Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
The most comprehensive neuroanatomical atlas on the expression of three glycoprotein hormone receptors, namely, TSHRs, LHCGRs, and FSHRs, was mapped using RNAscope, a technology that allows the detection of mRNA at single-transcript level.
Conditional knockout mice revealed that oxytocin secretion from the paraventricular hypothalamic nucleus suppresses hyperphagic obesity partly via the oxytocin receptor expressed in the arcuate hypothalamic nucleus.
Weisheng Wang, Peter J Schuette ... Avishek Adhikari
Activity in the hypothalamic dorsal premammillary nucleus predicts future escape from threat, represents escape velocity, and controls escape velocity via a projection to the brainstem.
tTARGIT AAVs offer a new approach to manipulate intersectional populations that produce selective and robust transgene expression and are easily modified.
RAI1 regulates molecular signalling and intrinsic excitability of hypothalamic brain-derived neurotrophic factor neurons important for energy homeostasis.