169 results found
    1. Physics of Living Systems

    Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law

    Thomas C Day, Stephanie S Höhn ... Peter J Yunker
    The distributions of cellular neighborhood volumes in two very different multicellular species - snowflake yeast and Volvox carteri - are found to obey a common functional form arising from maximum entropy consideration, despite great differences in their cell division processes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces

    Vladimir A Volkov, Pim J Huis in 't Veld ... Andrea Musacchio
    Multiple NDC80 complexes in the outer kinetochore cooperate to bind the ends of depolymerizing microtubules and harness their power stroke.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

    Oleg A Volkov, Lisa Kinch ... Margaret A Phillips
    A catalytically dead paralog activates its cognate enzyme through an allosteric mechanism that combined structural and phylogenomic analysis indicates arose through acquisition of a dimerization domain, suggesting a general model for how complex allostery evolves.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling

    Pim J Huis in 't Veld, Vladimir A Volkov ... Marileen Dogterom
    Binding of two macromolecular complexes allows kinetochores to capture force produced by the depolymerising ends of microtubules, allowing chromosomes to be transmitted from a mother cell to its two daughters.
    1. Physics of Living Systems
    2. Cell Biology

    Flagellar synchronization through direct hydrodynamic interactions

    Douglas R Brumley, Kirsty Y Wan ... Raymond E Goldstein
    A combination of experiment and theory shows that pairs of eukaryotic flagella can achieve robust synchronization solely through the action of the fluid that surrounds them.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Flagellar Beating: Row with the flow

    Benjamin M Friedrich, Ingmar H Riedel-Kruse
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    1. Evolutionary Biology

    Metabolic co-dependence drives the evolutionarily ancient Hydra–Chlorella symbiosis

    Mayuko Hamada, Katja Schröder ... Thomas CG Bosch
    The symbiotic relationship between Hydra and Chlorella is driven by metabolic co-dependence and characterized by changes in the photobiont genome in terms of lack of genes essential in free-living algae.
    1. Immunology and Inflammation

    Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

    David G Saliba, Pablo F Céspedes-Donoso ... Michael L Dustin
    TCR and CD40L microclusters are linked in synaptic ectosomes (extracellular vesicles) and released in the immunological synapse by helper T cells and induce dendritic cell maturation and cytokine production.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Direct measurement of conformational strain energy in protofilaments curling outward from disassembling microtubule tips

    Jonathan W Driver, Elisabeth A Geyer ... Charles L Asbury
    The protofilaments that curl outward from a disassembling microtubule tip carry a large amount of strain energy and they can drive movement with an efficiency similar to conventional motor proteins.
    1. Physics of Living Systems
    2. Microbiology and Infectious Disease

    Phototaxis: Life in focus

    Carol Dieckmann, Telsa Mittelmeier
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