Carine Gubelmann, Petra C Schwalie ... Bart Deplancke
A large-scale transcription factor screen reveals over twenty novel adipogenic regulators: most notably ZEB1, which exerts essential transcriptional control of fat cell differentiation.
Genome editing to insert a light-sensitive dimerization module directly into the EB1 microtubule plus end adaptor gene in human induced pluripotent stem cells enables local and acute optogenetic EB1 inactivation highlighting microtubule functions in developing neuronal growth cones.
Proper development depends on establishing precise gene expression patterns in spite of the inherent noise in transcription, shadow enhancers buffer this noise by binding distinct input transcription factors.
Neural representations are fast-evolving trajectories, and distinct components of these trajectories reappear during retrieval with distinct consequences for learning.
The ZEB2/ACSL4 axis acts as a novel metastatic metabolic pathway that stimulates both lipogenesis and fatty acid oxidation, resulting in enhanced breast cancer invasion and metastasis.
Samuel J Gonzalez, Julia M Heckel ... Melissa K Gardner
Computational modeling combined with biophysical and cellular experiments reveal that rapid binding to incomplete, partial microtubule binding sites facilitates tracking of the end-binding protein EB1 with growing microtubule plus-ends.
The sharp expression pattern driven by a classic, simple animal enhancer is determined by multiple molecular mechanisms, not only cooperative binding of the activating transcription factor as was previously thought.
Overexpression of PLK1 triggers oncogenic transformation and transcriptional reprogramming of prostate epithelial cells, which stimulates cell migration and invasion.