365 results found
    1. Developmental Biology

    Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

    Carine Gubelmann, Petra C Schwalie ... Bart Deplancke
    A large-scale transcription factor screen reveals over twenty novel adipogenic regulators: most notably ZEB1, which exerts essential transcriptional control of fat cell differentiation.
    1. Developmental Biology
    2. Neuroscience

    Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition

    Shalini Singh, Danielle Howell ... David J Solecki
    Neuronal progenitor cells autonomously inhibit polarization via the transcription factor Zeb1.
    1. Cell Biology
    2. Neuroscience

    Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant

    Alessandro Dema, Rabab Charafeddine ... Torsten Wittmann
    Genome editing to insert a light-sensitive dimerization module directly into the EB1 microtubule plus end adaptor gene in human induced pluripotent stem cells enables local and acute optogenetic EB1 inactivation highlighting microtubule functions in developing neuronal growth cones.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Shadow enhancers can suppress input transcription factor noise through distinct regulatory logic

    Rachel Waymack, Alvaro Fletcher ... Zeba Wunderlich
    Proper development depends on establishing precise gene expression patterns in spite of the inherent noise in transcription, shadow enhancers buffer this noise by binding distinct input transcription factors.
    1. Neuroscience

    Temporal structure in associative retrieval

    Zeb Kurth-Nelson, Gareth Barnes ... Peter Dayan
    Neural representations are fast-evolving trajectories, and distinct components of these trajectories reappear during retrieval with distinct consequences for learning.
    1. Cancer Biology

    A positive feedback loop between ZEB2 and ACSL4 regulates lipid metabolism to promote breast cancer metastasis

    Jiamin Lin, Pingping Zhang ... Na Yang
    The ZEB2/ACSL4 axis acts as a novel metastatic metabolic pathway that stimulates both lipogenesis and fatty acid oxidation, resulting in enhanced breast cancer invasion and metastasis.
    1. Cell Biology

    Rapid binding to protofilament edge sites facilitates tip tracking of EB1 at growing microtubule plus-ends

    Samuel J Gonzalez, Julia M Heckel ... Melissa K Gardner
    Computational modeling combined with biophysical and cellular experiments reveal that rapid binding to incomplete, partial microtubule binding sites facilitates tracking of the end-binding protein EB1 with growing microtubule plus-ends.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends

    Taylor A Reid, Courtney Coombes ... Melissa K Gardner
    EB1 targeting to growing microtubule plus-ends is facilitated by tapered microtubule tip structures.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity

    Jeehae Park, Javier Estrada ... Angela H DePace
    The sharp expression pattern driven by a classic, simple animal enhancer is determined by multiple molecular mechanisms, not only cooperative binding of the activating transcription factor as was previously thought.
    1. Cell Biology

    Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling

    Jianguo Wu, Andrei I Ivanov ... Zheng Fu
    Overexpression of PLK1 triggers oncogenic transformation and transcriptional reprogramming of prostate epithelial cells, which stimulates cell migration and invasion.

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