Distinct members of the Caenorhabditis elegans microbiota can have widely divergent effects on Orsay virus transmission, such that associated bacteria can effectively determine host susceptibility versus resistance to viral infection.

Evidence that C. elegans and mammals use homologous versions of the same protein (RIG-1) to activate antiviral defense mechanisms suggests that RIG-1 may have a conserved role in coupling virus recognition to virus destruction.

Genetic and biochemical analyses identify a pathway important for infection by many picornaviruses.

Systematically studying the expression, small RNA-binding partners, and loss-of-function phenotypes of all 19 Argonautes uncovers how small RNA regulatory pathways function and interact in Caenorhabditis elegans, a long-standing model for small RNA biology and RNAi.

To leverage the tools, resources and knowledge that exist for C. elegans so that we can study ecology, evolution and other aspects of biology, we need to understand the natural history of this important model organism.

Biochemical and structural analyses unravel how two RIG-I-like helicases function together to promote antiviral defense and illustrates the diverse ways innate immunity evolved.

Novel virus-host systems yield insights into how Lepidopterans (moths and butterflies) combat RNA virus infection and reveal that poxvirus A51R proteins can suppress the host's immune system and stabilize microtubules in host cells.