1,556 results found
    1. Neuroscience

    A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels

    Yucheng Xiao, Jonathan W Theile ... Theodore R Cummins
    A-type fibroblast growth factor homologous factors generate resurgent currents in tetrodotoxin-resistant voltage-gated sodium channels, increase repetitive firing of sensory neurons, and provide a potentially important target for pain treatment strategies.
    1. Developmental Biology

    The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling

    Seyed Javad Rasouli, Mohamed El-Brolosy ... Didier Y Stainier
    Endocardial Klf2 regulates cardiomyocyte adhesion and myocardial wall integrity by modulating FGF signaling in zebrafish.
    1. Computational and Systems Biology

    Trajectories of childhood immune development and respiratory health relevant to asthma and allergy

    Howard HF Tang, Shu Mei Teo ... Michael Inouye
    Unsupervised cluster analysis identified similar groups of children in different cohorts, with distinct developmental patterns of immunorespiratory health, asthma and allergy.
    1. Structural Biology and Molecular Biophysics

    Gating mechanisms during actin filament elongation by formins

    Fikret Aydin, Naomi Courtemanche ... Gregory A Voth
    Formins slow elongation of actin filament by either sterically blocking the addition of actin subunits or flattening the helical twist of the filament end.
    1. Developmental Biology
    2. Neuroscience

    Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling

    Sung-Ho Huh, Mark E Warchol, David M Ornitz
    Otic epithelial Fibroblast Growth Factors control the number of cochlear sensory progenitor cells through an FGF responsive periotic mesenchyme.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Crk proteins transduce FGF signaling to promote lens fiber cell elongation

    Tamica N Collins, Yingyu Mao ... Xin Zhang
    Crk proteins are critical mediators of FGF signaling to control cell shape changes.
    1. Developmental Biology

    Etv transcription factors functionally diverge from their upstream FGF signaling in lens development

    Ankur Garg, Abdul Hannan ... Xin Zhang
    The FGF-induced Etv transcription factors operate outside the confines of upstream signaling in lens development.
    1. Stem Cells and Regenerative Medicine

    Near-perfect precise on-target editing of human hematopoietic stem and progenitor cells

    Fanny-Mei Cloarec-Ung, Jamie Beaulieu ... David JHF Knapp
    Precision genome editing in human hematopoietic stem and progenitor cells can achieve near-perfect efficiency with tunable zygosity, thus enabling isogenic disease modeling for monogenic blood disorders and improving therapeutic applications.
    1. Developmental Biology
    2. Neuroscience

    Dual role of FOXG1 in regulating gliogenesis in the developing neocortex via the FGF signalling pathway

    Mahima Bose, Ishita Talwar ... Shubha Tole
    Foxg1 regulates gliogenesis in the mouse neocortex by modulating FGF signalling and integrating intrinsic and extrinsic mechanisms to ensure a balanced production of neurons, astrocytes, and oligodendrocytes in the brain.
    1. Developmental Biology

    BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity

    Richard H Row, Amy Pegg ... Benjamin L Martin
    Interplay between FGF-induced bHLH transcription factors and BMP-induced bHLH inhibitory id genes govern mesodermal cell fate choice along the mediolateral axis in both zebrafish and mouse.

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