In invertebrate and vertebrate models of Spinal Muscular Atrophy, diminished SMN protein causes Gemin3-dependent decreases in microRNA function, leading to upregulated M2 muscarinic receptor and deleterious consequences.

Activity-guided fractionation identifies the first bacterial metabolite that potently induces a prion in nature.

Jaw joint regulatory sequence 1 (JRS1) is deeply conserved in most jawed vertebrates and displays a specific enhancer activity in the developing primary jaw joint that contributes to early nkx3.2 gene expression and jaw joint morphology.

The activity of a set of GABAergic neurons is causally linked with a locomotory pattern in moving animals, and the mechanisms underlying the neuromodulatory role of GABA are illuminated.

Two small, energy independent stress effectors are able to counteract all of the major insults imposed by severe water loss.

The genomic features associated with a gene fate to loss have been retained for approximately 500 million years during evolution, and the genes with these features exhibit restricted expression profiles, leading to the genes being less important.

Two putative long noncoding RNAs in zebrafish encode micropeptides with homology to the vertebrate-specific chromatin architectural protein, Hmgn1, which are required for development of vertebrate-specific brain cell types.

Zebrafish have lubricated joints similar to ours and are a tractable model for arthritis research.

In the brain of medaka fish, neuropeptide B acts directly downstream of estrogen in a female-specific but reversible manner to mediate female receptivity to male courtship.

Phylogenetic, biochemical, and genetic techniques reveal a novel and ancient member of the Perilipin family, termed Plin6, that functions to concentrate and traffic lipophilic skin pigment in teleost fish.