431 results found
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    A billion years arms-race between viruses, virophages, and eukaryotes

    Jose Gabriel Nino Barreat, Aris Katzourakis
    Phylogenetic analyses of the four core virion proteins support a new evolutionary model for the origin of the main groups of eukaryotic viruses in the kingdom Bamfordvirae.
    1. Neuroscience

    Uncovering temporal structure in hippocampal output patterns

    Kourosh Maboudi, Etienne Ackermann ... Caleb Kemere
    Machine learning models of coordinated hippocampal ensemble activity during sharp wave ripple activity encode structure that mirrors the place cell map expressed during exploration, and enable a new paradigm for analyzing and understanding this offline activity.
    1. Computational and Systems Biology
    2. Neuroscience

    A stochastic neuronal model predicts random search behaviors at multiple spatial scales in C. elegans

    William M Roberts, Steven B Augustine ... Shawn R Lockery
    A stochastic model of locomotory control in C. elegans based on an extensive new set of tracking data can explain and predict effects of ablations and mutations on behavior.
    1. Neuroscience

    Predicting individual traits from models of brain dynamics accurately and reliably using the Fisher kernel

    Christine Ahrends, Mark W Woolrich, Diego Vidaurre
    The HMM-Fisher kernel approach leverages individual signatures of brain dynamics for prediction, which can be used, for example, to search for brain dynamics-informed biomarkers of neuropsychiatric disease or predict treatment response.
    1. Neuroscience

    Statistical structure of locomotion and its modulation by odors

    Liangyu Tao, Siddhi Ozarkar ... Vikas Bhandawat
    A fly's locomotion can be decomposed into a small number of locomotor features which can be modulated by odors and other sensory information.
    1. Neuroscience

    Reproducible, data-driven characterization of sleep based on brain dynamics and transitions from whole-night fMRI

    Fan Nils Yang, Dante Picchioni ... Jeff H Duyn
    Whole-night fMRI-based sleep classification uncovers distinct substates within N2 and REM sleep stages, along with a transition structure between them.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Linking time-series of single-molecule experiments with molecular dynamics simulations by machine learning

    Yasuhiro Matsunaga, Yuji Sugita
    A general machine learning scheme for integrating time-series data from single-molecule experiments and molecular dynamics simulations is proposed and successfully demonstrated for the folding dynamics of the WW domain.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Bayesian inference of kinetic schemes for ion channels by Kalman filtering

    Jan L Münch, Fabian Paul ... Klaus Benndorf
    For analyzing time-dependent patch-clamp or patch-clamp fluorometry data of ion channels in terms of Markovian models, the superiority of Bayesian filtering with respect to traditional deterministic approaches is demonstrated enabling more reliable quantification of the parameters.
    1. Neuroscience

    Tripartite organization of brain state dynamics underlying spoken narrative comprehension

    Lanfang Liu, Jiahao Jiang ... Guosheng Ding
    Hidden Markov Modeling to fMRI data reveals how language comprehension arises from the dynamic interplay of large-scale brain networks.
    1. Neuroscience

    Control of entropy in neural models of environmental state

    Timothy H Muller, Rogier B Mars ... Jill X O'Reilly
    Evidence for neuromodulatory control of flexibility in human neural models.

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