10,883 results found
    1. Neuroscience

    Learning place cells, grid cells and invariances with excitatory and inhibitory plasticity

    Simon Nikolaus Weber, Henning Sprekeler
    A large variety of spatial representations implied in rodent navigation could arise robustly and rapidly from inputs with a weak spatial structure, by an interaction of excitatory and inhibitory synaptic plasticity.
    1. Neuroscience

    Cerebral blood flow and cerebrovascular reactivity are preserved in a mouse model of cerebral microvascular amyloidosis

    Leon P Munting, Marc Derieppe ... Louise van der Weerd
    The causal link between capillary amyloid‑β accumulation in the brain and cerebrovascular dysfunction, previously established in the Tg‑SwDI mouse model, is to be mitigated and remains to be fully uncovered.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

    Ricardo Guerrero-Ferreira, Nicholas MI Taylor ... Henning Stahlberg
    Two new polymorphic structures of recombinant human alpha-synuclein fibrils show striking differences to previous structures, while familial PD mutation sites remain crucial for protofilament interaction and fibril stability.
    1. Computational and Systems Biology
    2. Ecology

    Collaborative hunting in artificial agents with deep reinforcement learning

    Kazushi Tsutsui, Ryoya Tanaka ... Keisuke Fujii
    Collaborative hunting, characterized by the division of roles among predators, has emerged within a group of artificial agents through deep reinforcement learning.
    1. Computational and Systems Biology

    Step-to-step variations in human running reveal how humans run without falling

    Nidhi Seethapathi, Manoj Srinivasan
    Natural step-to-step variations show how human running is stabilized, underscoring the importance of center of mass control and showing how humans run without falling despite muscle noise and uneven terrain.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic tuning of gene expression enables cellular adaptation in the absence of pre-existing regulatory circuitry

    Lydia Freddolino, Jamie Yang ... Saeed Tavazoie
    Stochastic tuning of gene expression could be a common mechanism through which eukaryotic cells adapt to challenging external environments, potentially including survival of infectious organisms within the host and adaptation of cancer cells to chemotherapy.
  1. Meta-Research: Systemic racial disparities in funding rates at the National Science Foundation

    Christine Yifeng Chen, Sara S Kahanamoku ... Justin Hosbey
    White principal investigators applying to the National Science Foundation are consistently funded at higher rates than most non-white PIs.
    1. Computational and Systems Biology

    Associations of topic-specific peer review outcomes and institute and center award rates with funding disparities at the National Institutes of Health

    Michael S Lauer, Jamie Doyle ... Deepshikha Roychowdhury
    An analysis of peer review and funding outcomes of NIH research applications shows that funding disparities of topics preferred by African American Black investigators are not due to peer review preferences or biases.
    1. Cell Biology
    2. Genetics and Genomics

    Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

    Wouter Huiting, Suzanne L Dekker ... Steven Bergink
    Various genotoxic stresses trigger widespread aggregation of abundant, liquid-liquid phase separation-prone proteins, suggesting that genotoxic stress is a potential driver of disease-associated protein aggregation.
    1. Ecology
    2. Evolutionary Biology

    Proteomics reveals synergy between biomass degrading enzymes and inorganic Fenton chemistry in leaf-cutting ant colonies

    Morten Schiøtt, Jacobus J Boomsma
    Leaf-cutting ants use their fecal fluid to vector enzymes produced by their fungal symbiont to degrade plant biomass with a combination of degradation enzymes and Fenton chemistry.

Refine your results by:

Type
Research categories