The cell surface receptor LRP4, long recognized for postsynaptic functions, also plays a role as a presynaptic determinant of synapse formation by functioning through a downstream kinase pathway.

Chromosomal instability of cancer can be quantitatively measured by phylogenetic analysis of 200 tumor cells while using evolutionary principles to account for cellular selection.

Tyrosine phosphorylation of the intracellular domain of LRP1 serves as a molecular switch to regulate cellular cholesterol homeostasis through nuclear hormone receptor-mediated regulation of the cellular cholesterol exporter ABCA1.

Rhythms of lip movements entrain low-frequency brain oscillations and facilitate audiovisual speech processing.

The crystal structure of Norrie Disease Protein in complex with the extracellular cysteine-rich domain of Frizzled4 receptor and sucrose octasulfate reveals binding sites for Frizzled4, low density lipoprotein receptor related protein 5/6, and proteoglycan.

Live cell imaging and the in vivo dissection into distinct stages, called landmarks, represents a new methodology for analyzing meiosis in Arabidopsis and likely in other species as well.

Joint sequence, structure, and phylogenetic analyses identify highly conserved features in transmembrane domains of transient receptor potential (TRP) ion channel proteins that offer a novel explanation for how TRPs could integrate stimuli into cellular signals.

A shared molecular basis of proteoglycan accumulation, driven by Wnt signaling, underlies the parallel evolution of hypertrophied lips in East African cichlids.

Maf and Mafb differentially regulate MGE-derived cortical and hippocampal interneuron subtype and regional fate in part through promoting the expression of Mef2c and Pnoc during mouse embryonic neurogenesis.

Structure-based alignment of TRP channels enables comparison of structural changes, ion permeation pathways and ligand-binding sites and reveals over-representation of structures that represent non-conducting states.