2,112 results found
    1. Medicine

    Sensitivity of ID NOW and RT–PCR for detection of SARS-CoV-2 in an ambulatory population

    Yuan-Po Tu, Jameel Iqbal, Timothy O'Leary
    Although the ID NOW platform is less sensitive than RT–PCR for identification of SARS-CoV-2 infection, it provides high positive and negative predictive values in low-prevalence populations.
    1. Ecology
    2. Microbiology and Infectious Disease

    Competition for fluctuating resources reproduces statistics of species abundance over time across wide-ranging microbiotas

    Po-Yi Ho, Benjamin H Good, Kerwyn Casey Huang
    A simple model provides an accessible framework to infer macroscopic parameters of effective resource competition from longitudinal studies of microbial communities.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter

    Smriti Mishra, Brandy Verhalen ... Hassane S Mchaourab
    The conformational cycle of an ABC heterodimeric transporter reveals a divergence in the structural mechanism of ABC exporters.
    1. Structural Biology and Molecular Biophysics

    Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

    Po-Lin Chiu, Juan D Orjuela ... Thomas Walz
    Electron crystallography and molecular dynamics simulations show that a cholesterol sandwiched in between two neighboring aquaporin-0 tetramers stabilizes the association between the tetramers and thus promotes array formation.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Interdependent progression of bidirectional sister replisomes in E. coli

    Po Jui Chen, Anna B McMullin ... David Bates
    Physical association between sister replisomes early in the E. coli replication phase promotes rapid fork progression and inhibits fork stalling.
    1. Developmental Biology

    Conservation and divergence of related neuronal lineages in the Drosophila central brain

    Ying-Jou Lee, Ching-Po Yang ... Tzumin Lee
    Comprehensive, high-resolution lineage mapping of the fly brain reveals straightforward rules that drive neuronal complexity and probable evidence of brain evolution.
    1. Developmental Biology
    2. Evolutionary Biology

    The alternative regenerative strategy of bearded dragon unveils the key processes underlying vertebrate tooth renewal

    Lotta Salomies, Julia Eymann ... Nicolas Di-Poï
    Analysis of bearded dragon model reveals a novel tooth replacement strategy that demonstrates the critical importance of epithelial patterning, cell migration, and putative stem cell functional specialization in tissue regeneration.
    1. Developmental Biology
    2. Immunology and Inflammation

    Thymic macrophages consist of two populations with distinct localization and origin

    Tyng-An Zhou, Hsuan-Po Hsu ... Ivan L Dzhagalov
    Thymic macrophages are unique phagocytes with antigen-presenting abilities that comprise a Timd4+ subset of embryonic origin located in the cortex and a Cx3cr1+ subset derived from adult hematopoietic stem cells residing in the medulla.
    1. Structural Biology and Molecular Biophysics

    Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state

    Keenan C Taylor, Po Wei Kang ... Charles R Sanders
    The intermediate state conformation of the human KCNQ1 potassium channel voltage sensor domain was determined, validated, and shown to be conductive under physiological conditions.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The lingering effects of Neanderthal introgression on human complex traits

    Xinzhu Wei, Christopher R Robles ... Sriram Sankararaman
    Genetic variants introgressed into modern humans from Neanderthals tend to be depleted in their contribution to heritable trait variation relative to modern human variants consistent with the action of purifying selection.

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