8,136 results found
    1. Computational and Systems Biology
    2. Neuroscience

    The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2

    Marieke MB Hoekstra, Maxime Jan ... Paul Franken
    Sleep-wake patterns, together with a suprachiasmatic nuclei-independent circadian factor, are necessary and sufficient to maintain high-amplitude nychthemeral rhythms in PERIOD-2.
    1. Genetics and Genomics

    PRD-2 directly regulates casein kinase I and counteracts nonsense-mediated decay in the Neurospora circadian clock

    Christina M Kelliher, Randy Lambreghts ... Jay C Dunlap
    Casein kinase I, a pivotal kinase in the circadian clock encoded by ck-1a, is positively regulated by a novel RNA-binding protein that protects ck-1a transcripts from nonsense-mediated decay.
    1. Epidemiology and Global Health
    2. Medicine

    Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

    Nick K Jones, Lucy Rivett ... Michael P Weekes
    Diminished incidence of COVID-19 amongst healthcare workers in a comprehensive screening programme demonstrates how effective infection control measures and staff testing can prevent hospitals becoming independent 'hubs' of SARS-CoV-2 transmission.
    1. Neuroscience

    Epigenetic inheritance of circadian period in clonal cells

    Yan Li, Yongli Shan ... Joseph S Takahashi
    Global changes in gene expression associated with differential DNA methylation underlie epigenetic inheritance of circadian periodicity in cells.
    1. Epidemiology and Global Health
    2. Medicine

    Quantifying the impact of quarantine duration on COVID-19 transmission

    Peter Ashcroft, Sonja Lehtinen ... Sebastian Bonhoeffer
    Test-and-release quarantine strategies for traced contacts of confirmed SARS-CoV-2 cases and returning travellers can reduce average quarantine durations while remaining as effective as 10 days of quarantine without testing.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock

    Andrea Brenna, Iwona Olejniczak ... Urs Albrecht
    Cyclin-dependent kinase 5 regulates the circadian clock involving phosphorylation of the PER2 protein.
    1. Neuroscience

    A Toll-receptor map underlies structural brain plasticity

    Guiyi Li, Manuel G Forero ... Alicia Hidalgo
    Structural brain plasticity is encoded in the topographic distribution of Toll receptors and their ability to switch between alternative signalling outcomes, thus translating diverse sensory experience into structural change.
    1. Epidemiology and Global Health

    Reducing societal impacts of SARS-CoV-2 interventions through subnational implementation

    Mark M Dekker, Luc E Coffeng ... Sake J de Vlas
    An agent-based, population-scale, geographically explicit model, and integration of comprehensive data sources on demography, mobility, interactions and SARS-CoV-2 parameters, show that subnational implementations of intervention measures may provide better strategic choices for controlling future epidemics.
    1. Neuroscience

    Network instability dynamics drive a transient bursting period in the developing hippocampus in vivo

    Jürgen Graf, Vahid Rahmati ... Knut Kirmse
    Two-photon Ca2+ imaging and computational modeling reveal major developmental trajectories of spontaneous activity in developing CA1 and identify important roles of network bi-stability and synaptic input characteristics for hippocampal burstiness before eye opening.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Understanding drivers of phylogenetic clustering and terminal branch lengths distribution in epidemics of Mycobacterium tuberculosis

    Fabrizio Menardo
    Populations of Mycobacterium tuberculosis associated with clustering and shorter terminal branches are not necessarily transmitting more.

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