Promoter capture Hi-C in human iPSCs and iPSC-derived cardiomyocytes provides a platform to interrogate gene-regulatory dynamics of cardiomyocyte differentiation and directly links thousands of cardiovascular disease risk loci to hundreds of distal target genes.

At least three hypothalamic subsystems are involved in cardiovascular regulation in humans.

Radiotelemetric and genetic studies of peripheral tissue response show that a peripheral tissue can dynamically alter cardiovascular adaptation to changes in environmental oxygen.

Differences in the response of cardiomyocytes to oxygen deprivation in humans and chimpanzees may explain why humans are more prone to certain heart diseases.

Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.

The melanocortin-4 receptor knockout mouse exhibits a cardiomyopathy syndrome, which raises concerns about cardiovascular function in patients with the similar loss of function mutations, and perhaps even in the 1 in 1500 patients with heterozygous loss of the gene.

An integrative genome-wide approach supports a direct and collaborative role of ETS and AP-1 transcription factors in maintaining endothelial cell-specific and anti-inflammatory gene expression programs.

Trimethylamine-oxide (TMAO), a molecule present in seafood, reduces mortality and exerts beneficial effects on the circulatory system in heart failure rats.

The neurotransmitter serotonin helps to co-ordinate the respiratory and cardiovascular responses of newborns to oxygen deprivation.

Associations can be mapped using k-mer frequencies in sequencing reads without prior sequencing of a reference genome enabling detection of associations to variants of multiple types and outside of the reference.