486 results found
    1. Chromosomes and Gene Expression

    A promoter interaction map for cardiovascular disease genetics

    Lindsey E Montefiori et al.
    Promoter capture Hi-C in human iPSCs and iPSC-derived cardiomyocytes provides a platform to interrogate gene-regulatory dynamics of cardiomyocyte differentiation and directly links thousands of cardiovascular disease risk loci to hundreds of distal target genes.
    1. Medicine
    2. Neuroscience

    Deciphering the neural signature of human cardiovascular regulation

    Jorge Manuel et al.
    At least three hypothalamic subsystems are involved in cardiovascular regulation in humans.
    1. Medicine

    Cardiovascular adaptation to hypoxia and the role of peripheral resistance

    Andrew S Cowburn et al.
    Radiotelemetric and genetic studies of peripheral tissue response show that a peripheral tissue can dynamically alter cardiovascular adaptation to changes in environmental oxygen.
    1. Evolutionary Biology

    Stem Cells: Getting to the heart of cardiovascular evolution in humans

    Alex Pollen, Bryan J Pavlovic
    Differences in the response of cardiomyocytes to oxygen deprivation in humans and chimpanzees may explain why humans are more prone to certain heart diseases.
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    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation

    CM Schooling et al.
    Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.
    1. Medicine

    Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy

    Michael J Litt et al.
    The melanocortin-4 receptor knockout mouse exhibits a cardiomyopathy syndrome, which raises concerns about cardiovascular function in patients with the similar loss of function mutations, and perhaps even in the 1 in 1500 patients with heterozygous loss of the gene.
    1. Chromosomes and Gene Expression

    Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells

    Nicholas T Hogan et al.
    An integrative genome-wide approach supports a direct and collaborative role of ETS and AP-1 transcription factors in maintaining endothelial cell-specific and anti-inflammatory gene expression programs.
    1. Medicine

    TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats

    Marta Gawrys-Kopczynska et al.
    Trimethylamine-oxide (TMAO), a molecule present in seafood, reduces mortality and exerts beneficial effects on the circulatory system in heart failure rats.
    1. Neuroscience

    Autoresuscitation: The central role of serotonin

    Gary C Mouradian, Matthew R Hodges
    The neurotransmitter serotonin helps to co-ordinate the respiratory and cardiovascular responses of newborns to oxygen deprivation.
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    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Association mapping from sequencing reads using k-mers

    Atif Rahman et al.
    Associations can be mapped using k-mer frequencies in sequencing reads without prior sequencing of a reference genome enabling detection of associations to variants of multiple types and outside of the reference.

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