76 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Juxtaposition of heterozygous and homozygous regions causes reciprocal crossover remodelling via interference during Arabidopsis meiosis

    Piotr A Ziolkowski, Luke E Berchowitz ... Ian R Henderson
    Heterozygosity changes the balance between interfering and non-interfering crossovers during Arabidopsis meiosis.
    1. Genetics and Genomics
    2. Physics of Living Systems

    Coarsening dynamics can explain meiotic crossover patterning in both the presence and absence of the synaptonemal complex

    John A Fozard, Chris Morgan, Martin Howard
    Mathematical modelling, together with super-resolution imaging in Arabidopsis, demonstrates that a recently proposed coarsening model for meiotic crossover interference can explain the dynamic patterning of crossovers in many contexts, including in zyp1 and pch2 chromosome structure mutants.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A compartmentalized signaling network mediates crossover control in meiosis

    Liangyu Zhang, Simone Köhler ... Abby F Dernburg
    A regulatory circuit that localizes to the synaptonemal complex, a liquid crystalline compartment between chromosomes, ensures crossing-over while limiting the number of crossovers between homologous chromosomes during meiosis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors

    Ofer Rog, Simone Köhler, Abby F Dernburg
    Formation of a phase-separated interface between homologous chromosomes during meiosis enables regulatory signals to spread in cis over long distances, illuminating the longstanding mystery of crossover interference.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Non-crossover gene conversions show strong GC bias and unexpected clustering in humans

    Amy L Williams, Giulio Genovese ... Molly Przeworski
    In humans, non-crossover gene conversion events transmit GC alleles in 68% of cases and exhibit a complex pattern of multiple disconnected tracts clustered within 20–30 kilobase intervals.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation in Caenorhabditis elegans

    Bhumil Patel, Maryke Grobler ... Needhi Bhalla
    By regulating the chromosome axis component and meiotic HORMAD, HIM-3, the conserved AAA-ATPase PCH-2 controls the number and distribution of meiotic recombination events.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Reversions mask the contribution of adaptive evolution in microbiomes

    Paul A Torrillo, Tami D Lieberman
    The timescale dependence of dN/dS in bacteria is better explained by adaptive than purifying dynamics, suggesting comparative genomics can underestimate past adaptation.
    1. Genetics and Genomics

    A method for low-coverage single-gamete sequence analysis demonstrates adherence to Mendel’s first law across a large sample of human sperm

    Sara A Carioscia, Kathryn J Weaver ... Rajiv C McCoy
    A computational method and genome-wide scan of low-coverage single-cell sequencing data from a large sample of human sperm suggests balanced transmission of alleles to the gamete pool.
    1. Genetics and Genomics
    2. Plant Biology

    The genomic landscape of meiotic crossovers and gene conversions in Arabidopsis thaliana

    Erik Wijnker, Geo Velikkakam James ... Korbinian Schneeberger
    A comprehensive and genome-wide description of the genomic make-up and frequency of meiotic recombination in Arabidopsis thaliana reveals regional preferences, including nucleosome-free regions, and two associated recombination motifs.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop.

    Saravanapriah Nadarajan, Talley J Lambert ... Monica P Colaiácovo
    PLK-1/2-mediated SYP-4 phosphorylation is dependent on crossover precursor formation, triggering a switch in the dynamic state of the synaptonemal complex that reduces the formation of further double-strand breaks at late meiotic prophase.

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