Silvia Ardissone, Coralie Fumeaux ... Patrick H Viollier
A multi-layered and conserved cell cycle mechanism prevents capsulation, long known as a bacterial virulence determinant, in G1-phase and concurrently licenses bacteriophage-mediated genetic exchange prior to entry into S-phase.
Aljoscha Schulze, Alex Gomez-Marin ... Matthieu Louis
A computational model for the control of chemotaxis in the Drosophila larva clarifies the link between the peripheral encoding of naturalistic olfactory stimuli and action selection.
A neural circuit that can selectively induce sleep-like patterns in small regions of the brain demonstrates how sleep and arousal states may be controlled in local brain regions.
The expression of the major circadian component CLOCK is a key regulator of stemness in breast cancer cells, which can be a novel strategy for breast cancer treatment.
Optogenetic and electrical low-frequency stimulation in the sclerotic hippocampus prevents the emergence of spontaneous focal and evoked generalized seizures in a mouse epilepsy model.
Francie Moehring, Ashley M Cowie ... Cheryl L Stucky
Keratinocytes are critical for normal innocuous and noxious touch through their mechanically evoked ATP release and subsequent signaling to P2X4 channels on sensory neurons.
Matthew B Stone, Sarah A Shelby ... Sarah L Veatch
Clustering the B cell receptor generates a membrane domain analogous to the liquid-ordered phase, localizing proteins involved in early receptor activation.
Nana Naetar, Konstantina Georgiou ... Roland Foisner
The lamin A/C binding protein LAP2α inhibits formation of higher order lamin structures in the nuclear interior in a lamin A/C-phosphorylation-independent manner, thereby regulating chromatin mobility.