414 results found
    1. Microbiology and Infectious Disease

    Cell cycle constraints on capsulation and bacteriophage susceptibility

    Silvia Ardissone, Coralie Fumeaux ... Patrick H Viollier
    A multi-layered and conserved cell cycle mechanism prevents capsulation, long known as a bacterial virulence determinant, in G1-phase and concurrently licenses bacteriophage-mediated genetic exchange prior to entry into S-phase.
    1. Neuroscience

    Aberrant hippocampal Ca2+ microwaves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators

    Nicola Masala, Manuel Mittag ... Tony Kelly
    Common adeno-associated viral transduction procedures induce artefactual spatially confined Ca2+ waves in the hippocampus.
    1. Computational and Systems Biology
    2. Neuroscience

    Dynamical feature extraction at the sensory periphery guides chemotaxis

    Aljoscha Schulze, Alex Gomez-Marin ... Matthieu Louis
    A computational model for the control of chemotaxis in the Drosophila larva clarifies the link between the peripheral encoding of naturalistic olfactory stimuli and action selection.
    1. Neuroscience

    Thalamic reticular nucleus induces fast and local modulation of arousal state

    Laura D Lewis, Jakob Voigts ... Emery N Brown
    A neural circuit that can selectively induce sleep-like patterns in small regions of the brain demonstrates how sleep and arousal states may be controlled in local brain regions.
    1. Cancer Biology

    Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells

    Takashi Ogino, Naoya Matsunaga ... Shigehiro Ohdo
    The expression of the major circadian component CLOCK is a key regulator of stemness in breast cancer cells, which can be a novel strategy for breast cancer treatment.
    1. Microbiology and Infectious Disease

    Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity

    Patpicha Arunsan, Wannaporn Ittiprasert ... Thewarach Laha
    Gene knockout of liver fluke granulin by CRISPR/Cas9 attenuates the virulence of infection with a carcinogenic liver fluke.
    1. Neuroscience

    Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy

    Enya Paschen, Claudio Elgueta ... Carola A Haas
    Optogenetic and electrical low-frequency stimulation in the sclerotic hippocampus prevents the emergence of spontaneous focal and evoked generalized seizures in a mouse epilepsy model.
    1. Neuroscience

    Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling

    Francie Moehring, Ashley M Cowie ... Cheryl L Stucky
    Keratinocytes are critical for normal innocuous and noxious touch through their mechanically evoked ATP release and subsequent signaling to P2X4 channels on sensory neurons.
    1. Immunology and Inflammation

    Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes

    Matthew B Stone, Sarah A Shelby ... Sarah L Veatch
    Clustering the B cell receptor generates a membrane domain analogous to the liquid-ordered phase, localizing proteins involved in early receptor activation.
    1. Cell Biology

    LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

    Nana Naetar, Konstantina Georgiou ... Roland Foisner
    The lamin A/C binding protein LAP2α inhibits formation of higher order lamin structures in the nuclear interior in a lamin A/C-phosphorylation-independent manner, thereby regulating chromatin mobility.

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