Aaron Arvey, Joris van der Veeken ... Alexander Y Rudensky
There is limited epigenetic conservation of lineage-specific DNA elements in Treg cells, and genetic variation in Treg cell specific enhancers is associated with autoimmune disease.
Frank Wolfgang Albert, Joshua S Bloom ... Leonid Kruglyak
A genetic mapping study in more than 1000 yeast individuals reveals the complexity of trans-acting genetic influences on transcriptome variation in unprecedented depth and detail.
Elizabeth R Jerison, Sergey Kryazhimskiy ... Michael M Desai
Substantial heritable genetic variation in adaptability and the pleiotropic consequences of adaptation exists in budding yeast, and can be explained by a combination of fitness and specific segregating alleles.
Chong Li, Marie R Culhane ... Montserrat Torremorell
Vaccination has the potential to decrease swine influenza diversification by restricting influenza virus co-infections and reassortment events in pigs.
The expression of small RNAs (or sRNAs) is regulated not only by mRNA expression, but also by their own regulatory elements and by sRNA biogenesis genes.
Elizabeth ML Duxbury, Jonathan P Day ... Ben Longdon
A history of coevolution increases genetic variation in the susceptibility of Drosophila to viruses, largely by introducing major-effect resistance polymorphisms into populations.
Maria Gutierrez-Arcelus, Tuuli Lappalainen ... Emmanouil T Dermitzakis
Detailed analysis of umbilical cord cells shows that the associations between DNA methylation, gene expression and genetic variation are complex and context-dependent.
Leveraging the US Health and Retirement Study and C. elegans genetics reveals ALDH4A1/alh-6 as an evolutionarily conserved biomarker for normal muscle function over the lifespan.