8,516 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Determining growth rates from bright-field images of budding cells through identifying overlaps

    Julian MJ Pietsch, Alán F Muñoz ... Peter S Swain
    The BABY algorithm by estimating growth rates of individual cells from time-lapse microscopy images will help characterise the diversity in populations of budding cells, particularly differences in fitness.
    1. Cell Biology
    2. Computational and Systems Biology

    Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity

    Miriam Bracha Ginzberg, Nancy Chang ... Marc W Kirschner
    Cells employ two strategies, adjusting both their cell cycle lengths and their growth rates in a size-dependent manner, to correct aberrations in cell size.
    1. Microbiology and Infectious Disease

    Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa

    Camryn Pajon, Marla C Fortoul ... Robert P Smith
    The growth environment driven ratio of ATP to growth rate, called absolute growth, determines the final population composition of Staphylococcus aureus and Pseudomonas aeruginosa when in co-culture.
    1. Developmental Biology
    2. Genetics and Genomics

    Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth

    Ruby Oberin, Sigrid Petautschnig ... Patrick S Western
    Growth-delayed offspring generated from eggs that lacked normal epigenetic programming exhibited a remarkable capacity to undergo late gestational fetal growth recovery, despite inefficient placental function.
    1. Computational and Systems Biology

    A unified framework for measuring selection on cellular lineages and traits

    Shunpei Yamauchi, Takashi Nozoe ... Yuichi Wakamoto
    A unified framework for cell lineage statistics enables quantification of fitness landscapes and selection strength for any cellular lineage traits in a model-independent manner, and reveals the contributions of growth heterogeneity to population growth in diverse experimental model systems.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stem cell topography splits growth and homeostatic functions in the fish gill

    Julian Stolper, Elizabeth Mayela Ambrosio ... Lazaro Centanin
    The fish gill, an ever-growing organ with fast turnover rate, displays dedicated stem-cell populations for growth and homeostasis that are interchangeable upon external challenges.
    1. Developmental Biology

    Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

    Néstor Saiz, Laura Mora-Bitria ... Anna-Katerina Hadjantonakis
    A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
    1. Cell Biology
    2. Computational and Systems Biology

    Quantifying absolute gene expression profiles reveals distinct regulation of central carbon metabolism genes in yeast

    Rosemary Yu, Egor Vorontsov ... Jens Nielsen
    Global gene expression control mechanisms are modeled using a large dataset consisting of absolute-quantitative proteomics, transcriptomics, and partial metabolomics of Saccharomyces cerevisiae at a wide range of growth conditions.
    1. Developmental Biology
    2. Ecology

    Body mass and growth rates predict protein intake across animals

    Stav Talal, Jon F Harrison ... Arianne J Cease
    Protein nutritional requirements decrease predictively with mass throughout ontogeny across the animal kingdom.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Distinguishing different modes of growth using single-cell data

    Prathitha Kar, Sriram Tiruvadi-Krishnan ... Ariel Amir
    Single-cell data analysis must be guided by an underlying model.

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