Label-free three-photon imaging of whole, uncleared intact organoids generated from Rett syndrome patients show shorter migration distances and slower migration speeds of mutant radially migrating neurons with more tortuous trajectories.

Activation of Wnt/β-catenin signaling in endothelial progenitors derived from human pluripotent stem cells partially induces the specialized blood–brain barrier phenotype while the same treatment in matured endothelial cells is less efficacious.

A novel methodological strategy based on machine learning has been developed to study brain evolution across species.

Using fetal magnetic resonance imaging (MRI), maturational changes in tissue microstructure can be derived using diffusion MRI which provide new insight into the fundamental neurobiological transitions occurring within the emerging thalamocortical white matter pathways.

Studies of heterogeneity in healthy brain aging reveal varying susceptibilities to aging and delayed development, which deepen aging-development understanding and promote prediction and diagnosis of cognitive decline and neurodegenerative diseases.

Inter-individual differences in miRNA expression during fetal cortical development informs genetic mechanisms for complex brain phenotypes.

Human pluripotent stem cell modeling of the ATOH1 lineage identifies a temporal shift in the expression of key transcriptional regulators in the developing human cerebellum, this molecular divergence may drive the protracted development of the human cerebellum compared to rodents.

Multimodal brain connectome analysis reveals patterns of structure–function coupling and links their developmental changes to cognitive function and transcriptomic architecture.

The coupling between neural oscillatory activity, haemodynamics, and metabolism is localised to the temporo-parietal region in response to social stimuli, providing evidence of the importance of investigating the energetic basis of brain functional specialisation.

An analysis of enhancer activity during mouse cerebellar development provides an invaluable resource for studying gene expression regulation by enhancers in the developing cerebellum and delivers a rich dataset of novel gene-enhancer associations providing a basis for future in-depth studies.