By controlling the SUMOylation of the protein CAR-1, the aging-regulating pathways downstream of the Insulin/IGF signaling cascade and of the germ cells of the nematode Caenorhabditis elegans are integrated.

Genetic background and dietary environment interact to reshape metabolic signalling networks, and the resulting signalling diversity can illuminate regulatory mechanisms of complex traits.

Multi-omic profiling of gene expression in response to reduced insulin/IGF-like-signalling reveals tissue-specific regulation of DNA damage and lysosomal mannosidase regulation of tissue homeostasis as pro-longevity responses.

The catalytic activity of a Drosophila neprilysin is critical to proper insulin expression and food intake by regulating homeostasis of distinct signaling peptides.

Modulation of insulin signalling could be an effective therapeutic approach against hexanucleotide repeat expansion related to c9ALS/FTD neurodegenerative diseases.

Yeast specific lipids promote the transport of lipid transfer protein (LTP) across the blood brain barrier to the neurons that regulate systemic insulin signaling.

By regulating protein translation within the neuron, insulin signaling can control neuronal activity by altering the release of neurotransmitter molecules.

A truncated, non-signaling insulin receptor regulates insulin sensitivity in the nematode C. elegans by sequestering insulin peptides and preventing their interaction with full length receptors.

A critical role of aCT in the distinct activation mechanism of insulin receptor and insulin-like growth factor 1 receptor.

Two functionally antagonizing groups of hormones directly regulate starvation-induced increase in locomotion via a common neural target in fruit flies.