The milk protein Mfge8 promotes fat uptake and slows gastrointestinal motility to optimize nutrient absorption.

The use of nanopatterned hydrogels and specific integrin α5β1 peptidomimetic revealed that keratinocytes require an optimum inter-ligand spacing to best propagate intercellular forces and efficiently coordinate cell sheet migration.

Faster ligand-binding kinetics of integrin low-affinity states suggests that integrin binding to ligand and intracellular adapters and the actin cytoskeleton precedes their stabilization, together with tensile force, of the high-affinity, extended-open integrin conformation.

A new role for nephronectin and integrin α8 signaling during neural crest cell migration in the developing cornea has been identified.

Diverse biophysical properties of β1 and β3 integrin transmembrane and cytoplasmic domains result in distinct mechanisms of integrin activation and function.

Ankyrin-B – through interactions with PI3P lipids, dynactin and RabGAP1L – functions as a critical node in the protein circuitry underlying polarized recycling of α5β1-integrin to enable haptotaxis along fibronectin gradients.

Investigation of defined extracellular matrix proteins in differentiation of human pluripotent stem cells to cardiomyocytes reveals fibronectin, in addition to soluble factors, is required for cardiogenesis.

A novel two-step model for integrin activation primed by Cas during cell migration and spreading on multiple extracellular matrix ligands.

Integrin a11 is identified as an Osteolectin receptor, revealing a new mechanism for adult skeletal bone maintenance in which Osteolectin/a11b1 signaling promotes bone formation by activating the Wnt pathway.

Inhibition of ITGA2-mediated cancer cell-collagen interaction or targeting focal adhesion kinase activity may present an opportunity for therapeutic intervention of metastatic spread in ovarian cancer.